[HTML][HTML] Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation
N Lindson, SC Chepkin, W Ye… - … of systematic reviews, 2019 - ncbi.nlm.nih.gov
Background Nicotine replacement therapy (NRT) aims to replace nicotine from cigarettes to
ease the transition from cigarette smoking to abstinence. It works by reducing the intensity of …
ease the transition from cigarette smoking to abstinence. It works by reducing the intensity of …
Nicotine addiction
NL Benowitz - New England Journal of Medicine, 2010 - Mass Medical Soc
This review gives an account of the cigarette as a highly efficient nicotine delivery system. It
explains how nicotine induces pleasure, reduces stress and anxiety, and causes addiction …
explains how nicotine induces pleasure, reduces stress and anxiety, and causes addiction …
Nicotine replacement therapy versus control for smoking cessation
J Hartmann‐Boyce, SC Chepkin, W Ye… - Cochrane database …, 2018 - cochranelibrary.com
Background Nicotine replacement therapy (NRT) aims to temporarily replace much of the
nicotine from cigarettes to reduce motivation to smoke and nicotine withdrawal symptoms …
nicotine from cigarettes to reduce motivation to smoke and nicotine withdrawal symptoms …
Nicotine chemistry, metabolism, kinetics and biomarkers
NL Benowitz, J Hukkanen, P Jacob III - Nicotine psychopharmacology, 2009 - Springer
Nicotine underlies tobacco addiction, influences tobacco use patterns, and is used as a
pharmacological aid to smoking cessation. The absorption, distribution and disposition …
pharmacological aid to smoking cessation. The absorption, distribution and disposition …
Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics
NL Benowitz - Annual review of pharmacology and toxicology, 2009 - annualreviews.org
Nicotine sustains tobacco addiction, a major cause of disability and premature death.
Nicotine binds to nicotinic cholinergic receptors, facilitating neurotransmitter release and …
Nicotine binds to nicotinic cholinergic receptors, facilitating neurotransmitter release and …
Clinical pharmacology of nicotine: implications for understanding, preventing, and treating tobacco addiction
NL Benowitz - Clinical Pharmacology & Therapeutics, 2008 - Wiley Online Library
Understanding the basic and clinical pharmacology of nicotine provides a basis for
improved prevention and treatment of tobacco addiction. Nicotine acts on nicotinic …
improved prevention and treatment of tobacco addiction. Nicotine acts on nicotinic …
Interventions for preventing weight gain after smoking cessation
Background Most people who stop smoking gain weight. This can discourage some people
from making a quit attempt and risks offsetting some, but not all, of the health advantages of …
from making a quit attempt and risks offsetting some, but not all, of the health advantages of …
The neurobiology of addiction
GR Uhl, GF Koob, J Cable - Annals of the New York Academy …, 2019 - Wiley Online Library
Substance and alcohol use disorders impose large health and economic burdens on
individuals, families, communities, and society. Neither prevention nor treatment efforts are …
individuals, families, communities, and society. Neither prevention nor treatment efforts are …
Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind …
Background Substantial variability exists in therapeutic response and adverse effects with
pharmacotherapies for tobacco dependence. Biomarkers to optimise treatment choice for …
pharmacotherapies for tobacco dependence. Biomarkers to optimise treatment choice for …
Variation in CYP2A6 activity and personalized medicine
JA Tanner, RF Tyndale - Journal of personalized medicine, 2017 - mdpi.com
The cytochrome P450 2A6 (CYP2A6) enzyme metabolizes several clinically relevant
substrates, including nicotine—the primary psychoactive component in cigarette smoke. The …
substrates, including nicotine—the primary psychoactive component in cigarette smoke. The …