Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets
Z Hu, X Zhao, Z Wu, B Qu, M Yuan, Y Xing… - … and Targeted Therapy, 2024 - nature.com
Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …
multifaceted role in maintaining homeostasis among various tissues and organs. They are …
The relationship between the secondary vascular system and the lymphatic vascular system in fish
V Panara, Z Varaliová, J Wilting, K Koltowska… - Biological …, 2024 - Wiley Online Library
New technologies have resulted in a better understanding of blood and lymphatic vascular
heterogeneity at the cellular and molecular levels. However, we still need to learn more …
heterogeneity at the cellular and molecular levels. However, we still need to learn more …
The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling
A Schmidt, B Hrupka, F van Bebber… - The Journal of …, 2024 - Am Soc Clin Investig
The β-secretase BACE1 is a central drug target for Alzheimer's disease. Clinically tested,
BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known …
BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known …
Angpt1 binding to Tie1 regulates the signaling required for lymphatic vessel development in zebrafish
N Morooka, N Gui, K Ando, K Sako… - …, 2024 - journals.biologists.com
Development of the vascular system is regulated by multiple signaling pathways mediated
by receptor tyrosine kinases. Among them, angiopoietin (Ang)/Tie signaling regulates …
by receptor tyrosine kinases. Among them, angiopoietin (Ang)/Tie signaling regulates …
[HTML][HTML] Review Commons Transfer: Multiple cis-regulatory elements control prox1a expression in distinct lymphatic vascular beds
V Panara, H Yu, D Peng, K Staxäng… - Development …, 2024 - ncbi.nlm.nih.gov
During embryonic development, lymphatic endothelial cell (LEC) precursors are
distinguished from blood endothelial cells by the expression of Prospero-related homeobox …
distinguished from blood endothelial cells by the expression of Prospero-related homeobox …
Multiple cis-regulatory elements control prox1a expression in distinct lymphatic vascular beds
V Panara, H Yu, D Peng, K Staxäng, M Hodik… - …, 2024 - journals.biologists.com
During embryonic development, lymphatic endothelial cell (LEC) precursors are
distinguished from blood endothelial cells by the expression of Prospero-related homeobox …
distinguished from blood endothelial cells by the expression of Prospero-related homeobox …
Idiopathic multicentric Castleman disease-TAFRO results in high levels of mTOR activator SVEP1, tissue factor, and endotheliopathy
C Lossos, J Brown, S Sheikhbahaei… - Blood Vessels …, 2024 - ashpublications.org
Idiopathic multicentric Castleman disease (iMCD) is an inflammatory disease associated
with a cytokine storm, activation of the PI3K/AKT/mTOR pathway, coagulopathy, and …
with a cytokine storm, activation of the PI3K/AKT/mTOR pathway, coagulopathy, and …
Proteomic profile analysis of plasma and aqueous humor from glaucoma and non-glaucomatous patients
CL Pessuti, CL Huang, A Banks, N Vo, L Jennings… - bioRxiv, 2024 - biorxiv.org
Purpose: Glaucoma, a multifactorial ocular neuropathic and age associated disease, can
lead to irreversible vision loss. Diagnosis involves assessing optic cupping (increased cup …
lead to irreversible vision loss. Diagnosis involves assessing optic cupping (increased cup …
The Relationship between the Secondary Vascular System and the Lymphatic Vascular System in Fish
Z Varaliová, V Panara, J Wilting, K Koltowska… - 2023 - preprints.org
New technologies have resulted in a better understanding of blood and lymphatic vascular
heterogeneity at the cellular and molecular levels. Meanwhile, we still need to learn more …
heterogeneity at the cellular and molecular levels. Meanwhile, we still need to learn more …
The emerging Janus face of SVEP1 in development and disease
JS Elenbaas, IH Jung, A Coler-Reilly, PC Lee… - Trends in Molecular …, 2023 - cell.com
Sushi, von Willebrand factor type A, EGF, and pentraxin domain containing 1 (SVEP1) is a
large extracellular matrix protein that is also detected in circulation. Recent plasma …
large extracellular matrix protein that is also detected in circulation. Recent plasma …