In recent years, some exogenous bioactive peptides have been shown to have promising
anti-aging effects. These exogenous peptides may have a mechanism similar to …

Cardiovascular disease (CVD) is the number one cause of death in the United States.
Advancing age is a primary risk factor for developing CVD. Estimates indicate that 20% of …

Vascular aging, a major risk factor for cardiovascular disease, contributes to morbidity and
mortality in older people. Mitochondria play an important role in vascular aging. In …

Abstract Background Mitochondria-derived peptides (MDPs) represent a recently discovered
family of peptides encoded by short open reading frames (ORFs) found within mitochondrial …

Our cells operate based on two distinct genomes that are enclosed in the nucleus and
mitochondria. The mitochondrial genome presumably originates from endosymbiotic …

ABSTRACT Introduction: Mitochondrial-derived peptides (MDPs) are encoded within the
mitochondrial genome. They signal within the cell or are released to act as …

Introduction The mitochondrial-derived peptides (MDPs) are a novel group of natural
occurring peptides that have important signaling functions and biological activity. Both …

The mitochondria produce specific peptides–mitochondrial-derived peptides–that mediate
the transcriptional stress response by their translocation into the nucleus and interaction with …

Our understanding of the molecular regulation of aging and age-related diseases is still in its
infancy, requiring in-depth characterization of the molecular landscape shaping these …

Mitochondria are increasingly being recognized as information hubs that sense cellular
changes and transmit messages to other cellular components, such as the nucleus, the …