Anthracyclines including doxorubicin (DOX) are still the most widely used and efficacious
antitumor drugs, although their cardiotoxicity is a significant cause of heart failure. Despite …

Mitochondrial dysfunction is critical for the development and progression of cardiovascular
diseases (CVDs). Complex-1 (CI) is an essential component of the mitochondrial electron …

Background Bradykinesia, tremor, rigidity and postural instability are the hallmark of
Parkinson's disease (PD). Non-motor symptoms including cognitive, behavioral, and …

The prevalence rates of heart failure (HF) are greater than 10% in individuals aged> 75
years, indicating an intrinsic link between aging and HF. It has been recognized that …

Down syndrome (DS) is characterized by trisomy of chromosome 21 and peculiar
phenotype. Humanin (HN) is a mitochondrial short 24-residue polypeptide whit anti …

Abstract S14G-humanin (HNG), an analog of the mitochondria-derived peptide humanin,
has demonstrated protective effects against various cardiovascular diseases. However, the …

Objective Acute myocardial infarction (AMI) ranks among the top contributors to sudden
death and disability worldwide. It should be noted that current therapies always cause …

Changes in mitochondrial function play a critical role in the basic biology of aging and age-
related disease. Mitochondria are typically thought of in the context of ATP production and …

Angiotensin II (AngII) is involved in the pathogenesis of hypertensive artery remodeling by
inducing a phenotypic switch in vascular smooth muscle cells [Gly14]-Humanin (HNG), a …

Abstract Context Ginsenoside Rb1 (Rb1) exerts many beneficial effects and protects against
cardiovascular disease. Objective To investigate whether Rb1 could attenuate age-related …