A viable blood substitute is still of great necessity throughout the world. Perfluorocarbon‐
based oxygen carriers (PFCOCs) are emulsions that take advantage of the high solubility of …

Novel drug delivery systems (DDSs) have become the mainstay of research in targeted
cancer therapy. By combining different therapeutic strategies, potential DDSs and …

Significance: The worldwide blood shortage has generated a significant demand for
alternatives to whole blood and packed red blood cells for use in transfusion therapy. One …

Type-1 Diabetes (T1D) is a devastating autoimmune disorder which results in the
destruction of beta cells within the pancreas. A promising treatment strategy for T1D is the …

Devising a robust, efficient and cost effective hemoglobin (Hb) purification strategy is one of
the key challenges in the development of Hb-based blood substitutes. The aim of this study …

Biomaterials have had a major impact on the practice of contemporary medicine and patient
care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers …

The abnormal tumor vascular system and long distances among cells inside tumors and
blood vessels lead to restricted oxygen content and diffusion impairment in the tumor …

Bioprinting is a recently developed technology that has great potential to manufacture
artificial tissues and organs for transplantation. Recent studies have demonstrated …

This article discusses current efforts to develop hemoglobin-based oxygen carriers as blood
substitutes in light of the worldwide shortage of safe and viable allogeneic donor blood …

This article reports on the current status of the research on blood substitutes with particular
attention on hemoglobin-based oxygen carriers (HBOCs). Insights on the physiological role …