[HTML][HTML] Transcriptional elongation control in developmental gene expression, aging, and disease

Y Aoi, A Shilatifard - Molecular cell, 2023 - cell.com
The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

Pre-mRNA splicing and its cotranscriptional connections

H Shenasa, DL Bentley - Trends in Genetics, 2023 - cell.com
Transcription of eukaryotic genes by RNA polymerase II (Pol II) yields RNA precursors
containing introns that must be spliced out and the flanking exons ligated together. Splicing …

[HTML][HTML] Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex

MR Puno, CD Lima - Cell, 2022 - cell.com
RNA quality control relies on co-factors and adaptors to identify and prepare substrates for
degradation by ribonucleases such as the 3′ to 5′ ribonucleolytic RNA exosome. Here …

Nsp14 of SARS-CoV-2 inhibits mRNA processing and nuclear export by targeting the nuclear cap-binding complex

J Katahira, T Ohmae, M Yasugi, R Sasaki… - Nucleic Acids …, 2023 - academic.oup.com
To facilitate selfish replication, viruses halt host gene expression in various ways. The
nuclear export of mRNA is one such process targeted by many viruses. SARS-CoV-2, the …

[HTML][HTML] Temporal-iCLIP captures co-transcriptional RNA-protein interactions

RA Cordiner, Y Dou, R Thomsen, A Bugai… - Nature …, 2023 - nature.com
Dynamic RNA-protein interactions govern the co-transcriptional packaging of RNA
polymerase II (RNAPII)-derived transcripts. Yet, our current understanding of this process in …

[HTML][HTML] Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex

E Dubiez, E Pellegrini, MF Brask, W Garland… - Cell Reports, 2024 - cell.com
The nuclear cap-binding complex (CBC) coordinates co-transcriptional maturation,
transport, or degradation of nascent RNA polymerase II (Pol II) transcripts. CBC with its …

[HTML][HTML] CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity

GA Holling, CA Chavel, AP Sharda… - Cellular & Molecular …, 2024 - nature.com
Metabolic flexibility has emerged as a critical determinant of CD8+ T-cell antitumor activity,
yet the mechanisms driving the metabolic flexibility of T cells have not been determined. In …

[HTML][HTML] The cap-binding complex CBC and the eukaryotic translation factor eIF4E: co-conspirators in cap-dependent RNA maturation and translation

JC Mars, M Ghram, B Culjkovic-Kraljacic, KLB Borden - Cancers, 2021 - mdpi.com
Simple Summary To produce the proteins needed for the cell to survive, the information in
the DNA is converted to a mobile form known as messenger RNA, which exits the cell …

[HTML][HTML] Cryo-EM structure of the CBC-ALYREF complex

BP Clarke, AE Angelos, M Mei, PS Hill, Y Xie, Y Ren - eLife, 2023 - elifesciences.org
In eukaryotes, RNAs transcribed by RNA Pol II are modified at the 5'end with a 7-
methylguanosine (m7G) cap, which is recognized by the nuclear cap binding complex …

Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA

P Keil, A Wulf, N Kachariya, S Reuscher… - Nucleic acids …, 2023 - academic.oup.com
RNA-binding proteins (RBPs) control every RNA metabolic process by multiple protein–RNA
and protein–protein interactions. Their roles have largely been analyzed by crude mutations …