Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF …
YJ Surh, KS Chun, HH Cha, SS Han, YS Keum… - Mutation Research …, 2001 - Elsevier
A wide array of phenolic substances, particularly those present in edible and medicinal
plants, have been reported to possess substantial anticarcinogenic and antimutagenic …
plants, have been reported to possess substantial anticarcinogenic and antimutagenic …
Molecular cues to implantation
Successful implantation is the result of reciprocal interactions between the implantation-
competent blastocyst and receptive uterus. Although various cellular aspects and molecular …
competent blastocyst and receptive uterus. Although various cellular aspects and molecular …
The role of cyclooxygenases in inflammation, cancer, and development
CS Williams, M Mann, RN DuBois - Oncogene, 1999 - nature.com
The cyclooxygenase (COX) enzymes catalyze a key step in the conversion of arachidonate
to PGH 2, the immediate substrate for a series of cell specific prostaglandin and …
to PGH 2, the immediate substrate for a series of cell specific prostaglandin and …
Multiple female reproductive failures in cyclooxygenase 2–deficient mice
H Lim, BC Paria, SK Das, JE Dinchuk, R Langenbach… - Cell, 1997 - cell.com
Cyclooxygenase (COX) is the rate-limiting enzyme in the synthesis of prostaglandins (PGs)
and exists in two isoforms, COX-1 and COX-2. In spite of long-standing speculation …
and exists in two isoforms, COX-1 and COX-2. In spite of long-standing speculation …
Suppression of intestinal polyposis in ApcΔ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
M Oshima, JE Dinchuk, SL Kargman, H Oshima… - Cell, 1996 - cell.com
Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H
2: constitutive COX-1 and inducible COX-2. To assess the role of COX-2 in colorectal …
2: constitutive COX-1 and inducible COX-2. To assess the role of COX-2 in colorectal …
Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential
M Tsujii, S Kawano, RN DuBois - Proceedings of the …, 1997 - National Acad Sciences
Recent epidemiologic studies have shown a 40–50% reduction in mortality from colorectal
cancer in individuals who take nonsteroidal antiinflammatory drugs on a regular basis …
cancer in individuals who take nonsteroidal antiinflammatory drugs on a regular basis …
Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
RA Gupta, RN DuBois - Nature Reviews Cancer, 2001 - nature.com
Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …
Cyclooxygenase inhibitors: from pharmacology to clinical read-outs
P Patrignani, C Patrono - Biochimica et Biophysica Acta (BBA)-Molecular …, 2015 - Elsevier
Acetylsalicylic acid (aspirin) is a prototypic cyclooxygenase (COX) inhibitor. It was
synthesized serendipitously from a natural compound, ie, salicylic acid, with known …
synthesized serendipitously from a natural compound, ie, salicylic acid, with known …
Mouse models for the study of colon carcinogenesis
The study of experimental colon carcinogenesis in rodents has a long history, dating back
almost 80 years. There are many advantages to studying the pathogenesis of carcinogen …
almost 80 years. There are many advantages to studying the pathogenesis of carcinogen …
COX-2: a molecular target for colorectal cancer prevention
JR Brown, RN DuBois - Journal of Clinical Oncology, 2005 - ascopubs.org
Cyclooxygenase (COX), a key enzyme in the prostanoid biosynthetic pathway, has received
considerable attention due to its role in human cancers. Observational and randomized …
considerable attention due to its role in human cancers. Observational and randomized …