Reactive oxygen species in metabolic and inflammatory signaling

SJ Forrester, DS Kikuchi, MS Hernandes, Q Xu… - Circulation …, 2018 - Am Heart Assoc
Reactive oxygen species (ROS) are well known for their role in mediating both physiological
and pathophysiological signal transduction. Enzymes and subcellular compartments that …

ROS-scavenging therapeutic hydrogels for modulation of the inflammatory response

YE Kim, J Kim - ACS Applied Materials & Interfaces, 2021 - ACS Publications
Although reactive oxygen species (ROS) are essential for cellular processes, excessive
ROS could be a major cause of various inflammatory diseases because of the oxidation of …

Heart disease and stroke statistics—2018 update: a report from the American Heart Association

EJ Benjamin, SS Virani, CW Callaway… - Circulation, 2018 - Am Heart Assoc
Summary Each year, the American Heart Association (AHA), in conjunction with the Centers
for Disease Control and Prevention, the National Institutes of Health, and other government …

Statin safety and associated adverse events: a scientific statement from the American Heart Association

CB Newman, D Preiss, JA Tobert… - … , and vascular biology, 2019 - Am Heart Assoc
One in 4 Americans> 40 years of age takes a statin to reduce the risk of myocardial
infarction, ischemic stroke, and other complications of atherosclerotic disease. The most …

Type 2 diabetes mellitus and heart failure: a scientific statement from the American Heart Association and the Heart Failure Society of America: this statement does not …

SM Dunlay, MM Givertz, D Aguilar, LA Allen, M Chan… - Circulation, 2019 - Am Heart Assoc
Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of
morbidity and mortality in patients with established disease. Secular trends in the …

[HTML][HTML] Incidence and mortality trend of congenital heart disease at the global, regional, and national level, 1990–2017

W Wu, J He, X Shao - Medicine, 2020 - journals.lww.com
Incidence and mortality trend of congenital heart disease at... : Medicine Incidence and mortality
trend of congenital heart disease at the global, regional, and national level, 1990–2017 : Medicine …

[HTML][HTML] Inflammatory responses and inflammation-associated diseases in organs

L Chen, H Deng, H Cui, J Fang, Z Zuo, J Deng, Y Li… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Inflammation is a biological response of the immune system that can be triggered by a
variety of factors, including pathogens, damaged cells and toxic compounds. These factors …

Obesity, kidney dysfunction and hypertension: mechanistic links

JE Hall, JM do Carmo, AA da Silva, Z Wang… - Nature reviews …, 2019 - nature.com
Excessive adiposity raises blood pressure and accounts for 65–75% of primary
hypertension, which is a major driver of cardiovascular and kidney diseases. In obesity …

Coronary Microvascular Disease Pathogenic Mechanisms and Therapeutic Options: JACC State-of-the-Art Review

VR Taqueti, MF Di Carli - Journal of the American College of Cardiology, 2018 - jacc.org
Coronary microvascular disease (CMD) refers to the subset of disorders affecting the
structure and function of the coronary microcirculation, is prevalent in patients across a …

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

Y Zheng, SH Ley, FB Hu - Nature reviews endocrinology, 2018 - nature.com
Globally, the number of people with diabetes mellitus has quadrupled in the past three
decades, and diabetes mellitus is the ninth major cause of death. About 1 in 11 adults …