Targeting protein-protein interactions (PPIs) has been recently recognized as an emerging
therapeutic approach for several diseases. Up today, more than half a million PPI …

Significance: It is generally accepted that reactive oxygen species (ROS) scavenging
molecules or antioxidants exert health-promoting effects and thus their consumption as food …

Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary dysfunctional disease,
characterized by progressive vascular remodeling. Inflammation is an increasingly …

KEAP1 promotes the ubiquitin-dependent degradation of NRF2 by assembling into a CUL3-
dependent ubiquitin ligase complex. Oxidative and electrophilic stress inhibit KEAP1 …

Pulmonary hypertension describes a heterogeneous disease defined by increased
pulmonary artery pressures, and progressive increase in pulmonary vascular resistance due …

NRF2 serves as the master regulator of oxidative stress resistance in mammalian cells.
Although NRF2 activation decreases tumorigenic events in normal cells, accumulating …

Pulmonary arterial hypertension (PAH) is a progressive and fatal disease without a cure.
The exact pathogenic mechanisms of PAH are complex and poorly understood, yet a …

Oxidative stress plays an important role in the pathogenesis of chronic heart failure (CHF) in
many tissues. Increasing evidence suggests that systemic activation of nuclear factor …

Rationale: Pulmonary arterial hypertension (PAH) is characterized by enhanced proliferation
of pulmonary artery smooth muscle cells (PASMCs) accompanying increased production of …

Abstract According to the World Symposium Pulmonary Hypertension (WSPH) classification,
pulmonary hypertension (PH) is classified into five categories based on etiology. Among …