The calcium–iron connection in ferroptosis-mediated neuronal death

S Gleitze, A Paula-Lima, MT Núñez… - Free Radical Biology and …, 2021 - Elsevier
Iron, through its participation in oxidation/reduction processes, is essential for the
physiological function of biological systems. In the brain, iron is involved in the development …

[HTML][HTML] Balance of activity during a critical period tunes a developing network

I Hunter, B Coulson, T Pettini, JJ Davies, J Parkin… - Elife, 2024 - elifesciences.org
Developing neural circuits are influenced by activity and are especially sensitive to changes
in activity during critical periods (CPs) of development. Changes occurring during a CP often …

[HTML][HTML] Menopause-Associated Depression: Impact of Oxidative Stress and Neuroinflammation on the Central Nervous System—A Review

G Liang, ASF Kow, R Yusof, CL Tham, YC Ho, MT Lee - Biomedicines, 2024 - mdpi.com
Perimenopausal depression, occurring shortly before or after menopause, is characterized
by symptoms such as emotional depression, anxiety, and stress, often accompanied by …

[HTML][HTML] Ryanodine receptor mediated calcium release contributes to ferroptosis induced in primary hippocampal neurons by GPX4 inhibition

S Gleitze, OA Ramírez, I Vega-Vásquez, J Yan… - Antioxidants, 2023 - mdpi.com
Ferroptosis, a newly described form of regulated cell death, is characterized by the iron-
dependent accumulation of lipid peroxides, glutathione depletion, mitochondrial alterations …

[HTML][HTML] Eveningness chronotype and depressive affective temperament associated with higher high-sensitivity C-reactive protein in unipolar and bipolar depression

L Orsolini, L Ricci, S Pompili, A Cicolini… - Journal of affective …, 2023 - Elsevier
Background Several studies investigated the role of inflammation in the etiopathogenesis of
mood disorders. The aim of our cross-sectional study is evaluating baseline high-sensitivity …

The effects of the superoxide dismutase mimetic, MnTMPyP, post hypoxia and oxygen glucose deprivation in isolated rat hippocampal slices

N Moreton, M Puzio, JJ O'Connor - Brain Research Bulletin, 2022 - Elsevier
The contributions of hypoxia, oxygen glucose deprivation (OGD) and oxidative stress, to the
pathophysiology of acute ischemic stroke (AIS) are well established and can lead to …

[HTML][HTML] Ionizing radiation alters functional neurotransmission in Drosophila larvae

Y Zhang, Y Zhang, C Shen, S Hao, W Duan… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction Patients undergoing cranial ionizing radiation therapy for brain malignancies
are at increased risk of long-term neurocognitive decline, which is poorly understood and …

APOE4 and sedentary lifestyle synergistically impair neurovascular function in the visual cortex of awake mice

C Hall, S Anderle, O Bonnar, J Henderson, K Shaw… - 2024 - researchsquare.com
Reduced cerebral blood flow occurs early in the development of Alzheimer's disease (AD),
suggesting an impairment in how the brain maintains its energy supply may contribute to …

Iron-Calcium Crosstalk in Neurodegenerative Diseases

M Kadian, G Sharma, A Kumar - Brain-Iron Cross Talk, 2022 - Springer
Iron and calcium have one thing in common: they are both required for appropriate neural
activity. Neuronal calcium impulses drive neurochemical release, proliferation of axon and …

Ndr2 deficiency prevents spatial memory decline and proteostasis alterations in the ageing hippocampus

M Angel - 2023 - repo.bibliothek.uni-halle.de
The serine-threonine kinase Ndr2 regulates dendritic arborization and integrin signalling.
Among other cellular processes, it has also been strongly implicated in the regulation of …