[HTML][HTML] Computational modeling of blood flow hemodynamics for biomechanical investigation of cardiac development and disease
The heart is the first functional organ in a developing embryo. Cardiac development
continues throughout developmental stages while the heart goes through a serious of …
continues throughout developmental stages while the heart goes through a serious of …
Zebrafish: A smart tool for heart disease research
L Zhang, J Zhou - Journal of Fish Biology, 2023 - Wiley Online Library
The increasing prevalence of heart disease poses a significant threat to human survival and
safety. However, the current treatments available for heart disease are quite limited …
safety. However, the current treatments available for heart disease are quite limited …
The myocardium utilizes a platelet-derived growth factor receptor alpha (Pdgfra)–phosphoinositide 3-kinase (PI3K) signaling cascade to steer toward the midline …
R Shrestha, T McCann, H Saravanan, J Lieberth… - Elife, 2023 - elifesciences.org
Coordinated cell movement is a fundamental process in organ formation. During heart
development, bilateral myocardial precursors collectively move toward the midline (cardiac …
development, bilateral myocardial precursors collectively move toward the midline (cardiac …
Environmental toxicant-mediated cardiovascular diseases: an insight into the mechanism and possible preventive strategy
JN Asiwe, B Oritsemuelebi - Toxicology and Environmental Health …, 2024 - Springer
Background Cardiovascular system is saddled with responsibility of pumping blood into
circulation, thereby providing nourishment to tissues and removal of metabolic wastes …
circulation, thereby providing nourishment to tissues and removal of metabolic wastes …
[HTML][HTML] A Great Catch for Investigating Inborn Errors of Metabolism—Insights Obtained from Zebrafish
M Breuer, SA Patten - Biomolecules, 2020 - mdpi.com
Inborn errors of metabolism cause abnormal synthesis, recycling, or breakdown of amino
acids, neurotransmitters, and other various metabolites. This aberrant homeostasis …
acids, neurotransmitters, and other various metabolites. This aberrant homeostasis …
Induced Pluripotent Stem Cell–Based Modeling of Single-Ventricle Congenital Heart Diseases
LE Parker, LM Kurzlechner, AP Landstrom - Current cardiology reports, 2023 - Springer
Abstract Purpose of Review Congenital heart disease includes a wide variety of structural
cardiac defects, the most severe of which are single ventricle defects (SVD). These patients …
cardiac defects, the most severe of which are single ventricle defects (SVD). These patients …
Using live imaging to examine early cardiac development in zebrafish
T McCann, R Shrestha, A Graham… - Cell Polarity Signaling …, 2022 - Springer
Visualizing dynamic cellular behaviors using live imaging is critical to the study of cell
movement and to the study of cellular and embryonic polarity. Similarly, live imaging can be …
movement and to the study of cellular and embryonic polarity. Similarly, live imaging can be …
[HTML][HTML] The myocardium utilizes Pdgfra-PI3K signaling to steer towards the midline during heart tube formation
R Shrestha, T McCann, H Saravanan, J Lieberth… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Coordinated cell movement is a fundamental process in organ formation. During heart
development, bilateral myocardial precursors collectively move towards the midline (cardiac …
development, bilateral myocardial precursors collectively move towards the midline (cardiac …
[HTML][HTML] Wild-Type Zebrafish (Danio rerio) Larvae as a Vertebrate Model for Diabetes and Comorbidities: A Review
M van de Venter, J Didloff, S Reddy, B Swanepoel… - Animals, 2020 - mdpi.com
Simple Summary Diabetes is predicted to become a major global pandemic in the not too
distant future; subsequently, there is an urgent need to develop new drugs to treat this …
distant future; subsequently, there is an urgent need to develop new drugs to treat this …
[HTML][HTML] Toward the effective bioengineering of a pathological tissue for cardiovascular disease modeling: old strategies and new frontiers for prevention, diagnosis …
L Iop - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
Cardiovascular diseases (CVDs) still represent the primary cause of mortality worldwide.
Preclinical modeling by recapitulating human pathophysiology is fundamental to advance …
Preclinical modeling by recapitulating human pathophysiology is fundamental to advance …