The global hearing therapeutic pipeline: 2021
B Isherwood, AC Gonçalves, R Cousins, R Holme - Drug discovery today, 2022 - Elsevier
Hearing loss is a serious condition affecting more than 1.5 billion people globally. Many
affected people benefit from the use of devices, such as hearing aids, but these do not …
affected people benefit from the use of devices, such as hearing aids, but these do not …
Age-related changes in the cochlea and vestibule: shared patterns and processes
V Paplou, NMA Schubert, SJ Pyott - Frontiers in neuroscience, 2021 - frontiersin.org
Both age-related hearing loss (ARHL) and age-related loss in vestibular function (ARVL) are
prevalent conditions with deleterious consequences on the health and quality of life. Age …
prevalent conditions with deleterious consequences on the health and quality of life. Age …
Hearing impairment is associated with cognitive decline, brain atrophy and tau pathology
Background Hearing impairment was recently identified as the most prominent risk factor for
dementia. However, the mechanisms underlying the link between hearing impairment and …
dementia. However, the mechanisms underlying the link between hearing impairment and …
Single-cell transcriptomic atlas of mouse cochlear aging
Progressive functional deterioration in the cochlea is associated with age-related hearing
loss (ARHL). However, the cellular and molecular basis underlying cochlear aging remains …
loss (ARHL). However, the cellular and molecular basis underlying cochlear aging remains …
Auditory sensory deprivation induced by noise exposure exacerbates cognitive decline in a mouse model of Alzheimer's disease
Although association between hearing impairment and dementia has been widely
documented by epidemiological studies, the role of auditory sensory deprivation in cognitive …
documented by epidemiological studies, the role of auditory sensory deprivation in cognitive …
Extended high-frequency hearing impairment despite a normal audiogram: Relation to early aging, speech-in-noise perception, cochlear function, and routine …
Objectives: Humans can hear up to 20 kHz. Emerging evidence suggests that hearing in the
extended high frequencies (EHFs;> 8 kHz) contributes to speech perception in noise. The …
extended high frequencies (EHFs;> 8 kHz) contributes to speech perception in noise. The …
[HTML][HTML] Noise-induced auditory damage affects hippocampus causing memory deficits in a model of early age-related hearing loss
F Paciello, A Pisani, M Rinaudo, S Cocco… - Neurobiology of …, 2023 - Elsevier
Several studies identified noise-induced hearing loss (NIHL) as a risk factor for sensory
aging and cognitive decline processes, including neurodegenerative diseases, such as …
aging and cognitive decline processes, including neurodegenerative diseases, such as …
Age‐related hearing loss and cognitive decline: MRI and cellular evidence
Extensive evidence supports the association between age‐related hearing loss (ARHL) and
cognitive decline. It is, however, unknown whether a causal relationship exists between …
cognitive decline. It is, however, unknown whether a causal relationship exists between …
The impact of hearing loss on cognitive impairment: the mediating role of depressive symptoms and the moderating role of social relationships
X Cao, Q Liu, J Liu, B Yang, J Zhou - Frontiers in Public Health, 2023 - frontiersin.org
Background Given the potentially negative effects of hearing loss on mental health and
cognitive function, it is critical to gain a better understanding of the mechanisms underlying …
cognitive function, it is critical to gain a better understanding of the mechanisms underlying …
Considering hearing loss as a modifiable risk factor for dementia
Introduction Accumulating evidence links hearing loss to impaired cognitive performance
and increased risk for dementia. Hearing loss can lead to deafferentation-induced atrophy of …
and increased risk for dementia. Hearing loss can lead to deafferentation-induced atrophy of …