Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

The regulation and preservation of distinct intracellular and extracellular solute
microenvironments is crucial for the maintenance of cellular homeostasis. In mammals, the …

Histone lysine crotonylation (Kcr), a novel posttranslational modification, is widespread as
acetylation (Kac); however, its roles are largely unknown. In this study, we report that histone …

Histone lysine crotonylation was first identified as a new type of post-translational
modification in 2011. In recent years, prominent progress has been made in the study of …

Metabolism regulates cardiovascular biology through multiple mechanisms, including
epigenetic modifications. Over the past two decades, experimental and preclinical studies …

Histone lysine crotonylation (Kcr), as a posttranslational modification, is widespread as
acetylation (Kac); however, its roles are largely unknown in kidney fibrosis. In this study, we …

Simple Summary Cancer stands as the leading cause of death among children and
adolescents in the United States. Some of these pediatric cancers are highly aggressive and …

Acute kidney injury (AKI) is a common disease, but lacking effective drug treatments.
Chromodomain Y‐like (CDYL) is a kind of chromodomain protein that has been implicated …

In recent decades, renal disease research has witnessed remarkable advances.
Experimental evidence in this field has highlighted the role of inflammation in kidney …

Pan-vascular diseases, based on systems biology theory, explore the commonalities and
individualities of important target organs such as cardiovascular, cerebrovascular, and …