Age-associated B cells
MP Cancro - Annual review of immunology, 2020 - annualreviews.org
The age-associated B cell subset has been the focus of increasing interest over the last
decade. These cells have a unique cell surface phenotype and transcriptional signature …
decade. These cells have a unique cell surface phenotype and transcriptional signature …
Is inflammageing influenced by the microbiota in the aged gut? A systematic review
CM Shintouo, T Mets, D Beckwee, I Bautmans… - Experimental …, 2020 - Elsevier
Ageing is characterized by a low-grade chronic inflammation marked by elevated circulating
levels of inflammatory mediators. This chronic inflammation occurring in the absence of …
levels of inflammatory mediators. This chronic inflammation occurring in the absence of …
Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood
It is widely accepted that aging is accompanied by remodelling of the immune system
including thymic atrophy and increased frequency of senescent T cells, leading to immune …
including thymic atrophy and increased frequency of senescent T cells, leading to immune …
Gut microbial changes, interactions, and their implications on human lifecycle: an ageing perspective
R Vemuri, R Gundamaraju, MD Shastri… - BioMed research …, 2018 - Wiley Online Library
Gut microbiota is established during birth and evolves with age, mostly maintaining the
commensal relationship with the host. A growing body of clinical evidence suggests an …
commensal relationship with the host. A growing body of clinical evidence suggests an …
Immunotoxicity of nanomaterials in health and disease: Current challenges and emerging approaches for identifying immune modifiers in susceptible populations
Nanosafety assessment has experienced an intense era of research during the past
decades driven by a vivid interest of regulators, industry, and society. Toxicological assays …
decades driven by a vivid interest of regulators, industry, and society. Toxicological assays …
Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors
V Decman, BJ Laidlaw, TA Doering, J Leng… - The Journal of …, 2012 - journals.aai.org
Aging is associated with suboptimal CD8 T cell responses to viral infections. It is not clear
whether these poor responses are due to environmental influences or quantitative and …
whether these poor responses are due to environmental influences or quantitative and …
The interaction between gut microbiota and age-related changes in immune function and inflammation
T Magrone, E Jirillo - Immunity & ageing, 2013 - Springer
Intestinal microbiota and gut immune systems interact each other, maintaining a condition of
homeostasis in the context of the intestinal habitat. However, both systems undergo …
homeostasis in the context of the intestinal habitat. However, both systems undergo …
Low avidity circulating SARS-CoV-2 reactive CD8+ T cells with proinflammatory TEMRA phenotype are associated with post-acute sequelae of COVID-19
K Paniskaki, MJ Konik, M Anft, H Heidecke… - Frontiers in …, 2023 - frontiersin.org
The role of adaptive SARS-CoV-2 specific immunity in post-acute sequelae of COVID-19
(PASC) is not well explored, although a growing population of convalescent COVID-19 …
(PASC) is not well explored, although a growing population of convalescent COVID-19 …
Thymic stromal cells: roles in atrophy and age-associated dysfunction of the thymus
S Cepeda, AV Griffith - Experimental gerontology, 2018 - Elsevier
Atrophy of the thymus, the primary site of T lymphocyte generation, is a hallmark of the aging
immune system. Age-associated thymic atrophy results in diminished output of new, naïve T …
immune system. Age-associated thymic atrophy results in diminished output of new, naïve T …
Moderate physical activity associated with a higher naïve/memory T-cell ratio in healthy old individuals: potential role of IL15
DB Bartlett, NA Duggal - Age and ageing, 2020 - academic.oup.com
Introduction ageing is accompanied by impairments in immune responses due to
remodelling of the immune system (immunesenescence). Additionally, a decline in habitual …
remodelling of the immune system (immunesenescence). Additionally, a decline in habitual …