The continual supply of ATP to the fundamental cellular processes that underpin skeletal
muscle contraction during exercise is essential for sports performance in events lasting …

A rise in body core temperature and loss of body water via sweating are natural
consequences of prolonged exercise in the heat. This review provides a comprehensive and …

Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to
adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence …

The study of the origin and implications of fatigue in exercise has been widely investigated,
but not completely understood given the complex multifactorial mechanisms involved. Then …

More than half of patients who recover from COVID-19 experience fatigue. We studied
fatigue using neuropsychological and neurophysiological investigations in post-COVID-19 …

Fatigue has been defined differently in the literature depending on the field of research. The
inconsistent use of the term fatigue complicated scientific communication, thereby limiting …

New Findings What is the topic of this review? We review sex differences within
physiological systems implicated in exercise performance; specifically, how they integrate to …

Once thought to be a waste product of anaerobic metabolism, lactate is now known to form
continuously under aerobic conditions. Shuttling between producer and consumer cells …

Muscle fatigue is a common complaint in clinical practice. In humans, muscle fatigue can be
defined as exercise-induced decrease in the ability to produce force. Here, to provide a …

One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that
occurs in response to resistance exercise. A large body of work shows that a mammalian …