The liver can precisely regulate its growth and mass. Surgical resection of hepatic lobes or
hepatocyte loss caused by viral or chemical injury triggers hepatocyte replication while …

This review summarizes the functional aspects, cellular kinetics and molecular mechanisms
related to liver regeneration. Liver regeneration is a model of regenerative growth of tissues …

Since its discovery more than 25 years ago, numerous studies have established that the
MET receptor is unique among tyrosine kinases. Signaling through MET is necessary for …

Although normally quiescent, the adult mammalian liver possesses a great capacity to
regenerate after different types of injuries in order to restore the lost liver mass and ensure …

β-catenin, a key component of the canonical Wnt pathway, is also regulated by tyrosine
phosphorylation that regulates its association to E-cadherin. Previously, we reported its …

Hepatocyte growth factor (HGF), the ligand for the receptor tyrosine kinase c-Met, is
composed of an α-chain containing four Kringle domains (K1–K4) and a serine protease …

Introduction: Bone marrow-derived mesenchymal stem cells (MSCs) can differentiate into
multiple cell types, including osteoblasts, chondrocytes, and adipocytes. These pluripotent …

Hepatocyte growth factor (HGF) activates the Met receptor tyrosine kinase by binding and
promoting receptor dimerization. Here we describe a mechanistic basis for designing Met …

OBJECTIVE The purpose of the current study was to determine whether double-stranded
adeno-associated virus (dsAAV)-mediated in vivo expression of β-cell growth factors …

Hepatocyte growth factor (HGF), a potent cytokine of mesenchymal origin, exhibits
polytrophic physiological responses, including proliferation, migration, and invasion, in a …