Highlights•MicroRNAs regulate cell cycle, glycolysis, chromatin state, survival and
differentiation of pluripotent stem cells.•Recent studies reveal new functions of microRNAs in …

A cardinal property of neural stem cells (NSCs) is their ability to adopt multiple fates upon
differentiation. The epigenome is widely seen as a read-out of cellular potential and a …

Gene regulation in embryonic stem cells (ESCs) has been extensively studied at the
epigenetic-transcriptional level, but not at the posttranscriptional level. Pumilio (Pum) …

Background Experimentalists are overwhelmed by high-throughput data and there is an
urgent need to condense information into simple hypotheses. For example, large amounts of …

Pluripotency describes the developmental capacity to give rise to all cell types in the adult
body. A comprehensive understanding of the molecular mechanisms that regulate …

The complexity of stem cell niches poses a tremendous challenge to understanding
mechanisms of extrinsic regulation of stem cell fate. In order to better understand niche …

Translational control plays a pivotal role in the regulation of the pluripotency network in
embryonic stem cells, but its effect on reprogramming somatic cells to pluripotency has not …

Functional genomics has demonstrated considerable success in inferring the inner working
of a cell through analysis of its response to various perturbations. In recent years several …

We demonstrate that the pluripotency gene OCT4 has a role in regulating differentiation via
Wnt signaling. OCT4 expression levels in human embryonic stem cells increases transiently …

Self‐organization is a process by which interacting cells organize and arrange themselves
in higher order structures and patterns. To achieve this, cells must have molecular …