Inflammation and immune mechanisms are crucially involved in the pathophysiology of the
development, acute damage cascades, and chronic course after ischemic stroke …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterised by cognitive
impairment, behavioural alteration, and functional decline. Over 130 AD-associated …

Ischemic stroke is the leading cause of immortal disability and death worldwide. For
treatment in the acute phase, it is necessary to control excessive reactive oxygen species …

Background The immune cell compartment of the mammalian brain changes dramatically
and peripheral T cells infiltrate the brain parenchyma during normal aging. However, the …

There is an ongoing need for accurate prognostic biomarkers in the milieu of acute ischemic
stroke (AIS) receiving reperfusion therapy. Neutrophil–lymphocyte ratio (NLR) has been …

Background Emerging evidence has shown that myeloid cells that infiltrate into the peri-
infarct region may influence the progression of ischemic stroke by interacting with microglia …

Cholinergic signaling is crucial in cognitive processes, and degenerating cholinergic
projections are a pathological hallmark in dementia. Use of cholinesterase inhibitors is …

The concept of the ischemic penumbra was originally defined as the area around a necrotic
stroke core and seen as the tissue at imminent risk of further damage. Today, the penumbra …

Ischemic stroke has been demonstrated to cause an imbalance of gut microbiota. However,
the change in gut microbiota-mediated bile acids (BAs) metabolites remains unclear. Here …

In dry age-related macular degeneration (AMD), inflammation plays a key role in disease
pathogenesis. Innate immune cells such as microglia and neutrophils infiltrate the sub …