Alzheimer's disease (AD), the most common form of neurodegenerative dementia in adults
worldwide, is a multifactorial and heterogeneous disorder characterized by the interaction of …

The amyloid Aβ-peptide (Aβ) is suspected to play a critical role in the cascade leading to AD
as the pathogen that causes neuronal and synaptic dysfunction and, eventually, cell death …

Saito et al developed a novel amyloid precursor protein (APP) knock-in mouse model (APP
NL-GF) for Alzheimer's disease (AD) to overcome the problem of overexpression of APP in …

Histopathological studies in Alzheimer's disease (AD) suggest severe and region-specific
neurodegeneration of the basal forebrain cholinergic system (BFCS). Here, we studied the …

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders
worldwide. Its incidence is gradually increasing because of an aging demographic …

Few studies have investigated in vivo changes of the cholinergic basal forebrain in
Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI), an at risk stage of …

Aging is characterized by progressive loss of cognitive and memory functions as well as
decrease in physical activities. In the present study, a human neural stem cell line (F3 NSC) …

Objectives: Amyloid-beta (Aβ) peptide deposition into insoluble plaques is a pathological
hallmark of Alzheimer's disease (AD), but soluble oligomeric Aβ is considered to be more …

Brain ageing leads to atrophy and degeneration of the cholinergic nervous system, resulting
in profound neurobehavioral and cognitive dysfunction from decreased acetylcholine …

Introduction: Alzheimer's disease and depression are health conditions affecting millions of
people around the world. Both are strongly related to the level of the neurotransmitter …