Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

Acetylcholinesterase inhibitors (ChEI) are the global standard of care for the symptomatic
treatment of Alzheimer's disease (AD) and show significant positive effects in …

Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …

Single cell RNA sequencing studies identified novel neurodegeneration-associated
microglial (MGnD/DAM) subtypes activated around cerebral amyloid plaques. Micro-RNA …

Alzheimer's disease (AD) is a neurodegenerative disease with subtle onset, early diagnosis
remains challenging. Accumulating evidence suggests that the emergence of retinal …

Proper functioning of the neural retina relies on the unique retinal environment regulated by
the blood–retinal barrier (BRB), which restricts the passage of solutes, fluids, and toxic …

The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

Optical coherence tomography angiography (OCT-A) was commercially introduced in 2014.
OCT-A allows a fast, non-invasive, three-dimensional analysis of the retinal vasculature from …

Human-induced pluripotent stem cells (hiPSCs) have provided new methods to study
neurodegenerative diseases. In addition to their wide application in neuronal disorders …

There is emerging evidence that amyloid beta protein (Aβ) and tau‐related lesions in the
retina are associated with Alzheimer's disease (AD). Aβ and hyperphosphorylated (p)‐tau …