Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …

The genome-wide architecture of chromatin-associated proteins that maintains chromosome
integrity and gene regulation is not well defined. Here we use chromatin …

The most fundamental feature of cellular form is size, which sets the scale of all cell
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …

Histone acetylation is a ubiquitous hallmark of transcription, but whether the link between
histone acetylation and transcription is causal or consequential has not been addressed …

Transcription factors (TFs) interact with several other proteins in the process of
transcriptional regulation. Here, we identify 6703 and 1536 protein–protein interactions for …

Acetyl-CoA is a key intermediate situated at the intersection of many metabolic pathways.
The reliance of histone acetylation on acetyl-CoA enables the coordination of gene …

A fundamental feature of cellular growth is that total protein and RNA amounts increase with
cell size to keep concentrations approximately constant. A key component of this is that …

Previous studies suggested that expression of most yeast mRNAs is dominated by either
transcription factor TFIID or SAGA. We re-examined the role of TFIID by rapid depletion of S …

For most genes, mRNA transcript abundance scales with cell size to ensure a constant
concentration. Scaling of mRNA synthesis rates with cell size plays an important role, with …