Nuclear pore complexes (NPCs) mediate communication between the nucleus and the
cytoplasm, and regulate gene expression by interacting with transcription and mRNA export …

For transcription initiation by RNA polymerase II (Pol II), all eukaryotes require assembly of
basal transcription machinery on the core promoter, a region located approximately in the …

Background Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder that
primarily affects the cerebellum and retina. SCA7 is caused by a polyglutamine expansion in …

The histone acetyltransferase Gcn5 is conserved throughout eukaryotes where it functions
as part of large multi-subunit transcriptional coactivator complexes that stimulate gene …

The influence of genome organization on transcription is central to our understanding of cell
type specification. Higher-order genome organization is established through short-and long …

Epigenetic histone modifiers are key regulators of cell fate decisions in normal and
malignant hematopoiesis. Their enzymatic activities are of particular significance as putative …

Nucleosome‐depleted regions (NDRs) at gene promoters support initiation of RNA
polymerase II transcription. Interestingly, transcription often initiates in both directions …

Dear Editor, Eukaryotic gene transcription by RNA polymerase II (Pol II) is highly regulated
and fine-tuned by diverse epigenetic complexes, which often function as coactivators or co …

The+ 1 nucleosome of yeast genes, within which reside transcription start sites, is
characterized by histone acetylation, by the displacement of an H2A-H2B dimer, and by a …

The study of epigenetics has greatly benefited from the development and application of
various chemical biology approaches. In this review, we highlight the key targets for …