External evaluation of population pharmacokinetic models of imatinib in adults diagnosed with chronic myeloid leukaemia

Á Corral Alaejos, A Zarzuelo Castañeda… - British Journal of …, 2022 - Wiley Online Library
Aims Imatinib is considered the standard first‐line treatment in newly diagnosed patients
with chronic‐phase myeloid leukaemia (CML). Several imatinib population pharmacokinetic …

Using Real‐World Data to Externally Evaluate Population Pharmacokinetic Models of Dexmedetomidine in Children and Infants

S McCann, VE Helfer, SJ Balevic… - The Journal of …, 2024 - Wiley Online Library
Dexmedetomidine is a sedative used in both adults and off‐label in children with
considerable reported pharmacokinetic (PK) interindividual variability affecting drug …

External Evaluation of Population Pharmacokinetic Models for High‐Dose Methotrexate in Adult Patients with Hematological Tumors

S Chen, L Huang, W Huang, Y Zheng… - The Journal of …, 2024 - Wiley Online Library
Currently, numerous population pharmacokinetic (popPK) models for methotrexate (MTX)
have been published for estimating PK parameters and variability. However, it is unclear …

Challenges associated with test dose pharmacokinetic predictions of high dose melphalan exposure in patients with multiple myeloma

CE Nath, A Grigg, SPA Rosser, J Estell… - European Journal of …, 2022 - Springer
Aim To evaluate the accuracy of melphalan test dose pharmacokinetic (PK) predictions of
the subsequent high dose (HDM) area under the concentration-versus-time curve (AUC) …

External Validation of a Vancomycin Population Pharmacokinetic Model and Developing a New Dosage Regimen in Neonates

CP Lim, SH Tseng, CCC Neoh, Q Chen… - European Journal of …, 2022 - Springer
Abstract Background and Objective Vancomycin is the drug of choice in the treatment of
MRSA infections. In a published vancomycin population pharmacokinetic study on neonates …