Introduction Alzheimer's disease (AD) represents a global health crisis. Treatments are
needed to prevent, delay the onset, slow the progression, improve cognition, and reduce …

Traumatic brain injury (TBI) is a major health concern worldwide and is classified based on
severity into mild, moderate, and severe. The mechanical injury in TBI leads to a metabolic …

Importance Intravenous edaravone is approved as a disease-modifying drug for patients
with amyotrophic lateral sclerosis (ALS), but evidence for efficacy is limited to short-term …

Free radicals are formed as a part of normal metabolic activities but are neutralized by the
endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This …

Pyrazolone is a well-known influential synthon for the synthesis of many molecules which
hold remarkable potential in the advancement of functional materials, coordination …

Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease
characterized by a permanent degeneration of both upper and lower motor neurons. Many …

Neuroinflammation is an important factor contributing to cognitive impairment and
neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) …

Background Oxidative stress (OS) is an imbalance between oxidant and antioxidant species
and, together with other numerous pathological mechanisms, leads to the degeneration and …

Edaravone, the first known free radical scavenger, has demonstrated cellular protective
properties in animals and humans. Owing to its antioxidant activity, edaravone modulates …

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower
motor neurons (MNs) leading to paralysis and, ultimately, death by respiratory failure 3–5 …