The replacement of articular cartilage through transplantation of chondrogenic cells or
preformed cartilage tissue represents a potential new avenue for the treatment of …

Purpose To provide a comprehensive overview of the basic science and clinical evidence
behind cartilage regeneration techniques as they relate to surgical management of chondral …

Articular cartilage repair remains a significant and growing clinical challenge with the aging
population. The native extracellular matrix (ECM) of articular cartilage is a 3D structure …

Human embryonic stem cells (hESCs) have the potential to offer a virtually unlimited source
of chondrogenic cells for use in cartilage repair and regeneration. We have recently shown …

The self-renewal and differentiation of human pluripotent stem cells (hPSCs) have typically
been studied in flat, two-dimensional (2D) environments. In this Perspective, we argue that …

Osteochondral (OC) defects are debilitating for patients and represent a significant clinical
problem for orthopedic surgeons as well as regenerative engineers due to their potential …

Bone substitutes can be designed to replicate physiological structure and function by
creating a microenvironment that supports crosstalk between bone and immune cells found …

An important aim of regenerative medicine is to restore tissue function with implantable,
laboratory-grown constructs that contain tissue-specific cells that replicate the function of …

The translational potential of mesenchymal stem/stromal cells (MSCs) is limited by their
rarity in somatic organs, heterogeneity, and need for harvest by invasive procedures …

Lung injury and fibrosis represent the most significant outcomes of severe and acute lung
disorders, including COVID-19. However, there are still no effective drugs to treat lung injury …