Generation of articular chondrocytes from human pluripotent stem cells
AM Craft, JS Rockel, Y Nartiss, RA Kandel… - Nature …, 2015 - nature.com
The replacement of articular cartilage through transplantation of chondrogenic cells or
preformed cartilage tissue represents a potential new avenue for the treatment of …
preformed cartilage tissue represents a potential new avenue for the treatment of …
[HTML][HTML] The clinical status of cartilage tissue regeneration in humans
B Mollon, R Kandel, J Chahal… - Osteoarthritis and …, 2013 - Elsevier
Purpose To provide a comprehensive overview of the basic science and clinical evidence
behind cartilage regeneration techniques as they relate to surgical management of chondral …
behind cartilage regeneration techniques as they relate to surgical management of chondral …
Bioinspired nanofibers support chondrogenesis for articular cartilage repair
JM Coburn, M Gibson, S Monagle… - Proceedings of the …, 2012 - National Acad Sciences
Articular cartilage repair remains a significant and growing clinical challenge with the aging
population. The native extracellular matrix (ECM) of articular cartilage is a 3D structure …
population. The native extracellular matrix (ECM) of articular cartilage is a 3D structure …
Cartilage repair using hyaluronan hydrogel-encapsulated human embryonic stem cell-derived chondrogenic cells
Human embryonic stem cells (hESCs) have the potential to offer a virtually unlimited source
of chondrogenic cells for use in cartilage repair and regeneration. We have recently shown …
of chondrogenic cells for use in cartilage repair and regeneration. We have recently shown …
Three-dimensional biomaterials for the study of human pluripotent stem cells
TP Kraehenbuehl, R Langer, LS Ferreira - Nature methods, 2011 - nature.com
The self-renewal and differentiation of human pluripotent stem cells (hPSCs) have typically
been studied in flat, two-dimensional (2D) environments. In this Perspective, we argue that …
been studied in flat, two-dimensional (2D) environments. In this Perspective, we argue that …
Osteochondral interface: regenerative engineering and challenges
N Yildirim, A Amanzhanova… - ACS Biomaterials …, 2023 - ACS Publications
Osteochondral (OC) defects are debilitating for patients and represent a significant clinical
problem for orthopedic surgeons as well as regenerative engineers due to their potential …
problem for orthopedic surgeons as well as regenerative engineers due to their potential …
Human iPSC-derived osteoblasts and osteoclasts together promote bone regeneration in 3D biomaterials
Bone substitutes can be designed to replicate physiological structure and function by
creating a microenvironment that supports crosstalk between bone and immune cells found …
creating a microenvironment that supports crosstalk between bone and immune cells found …
Comparative materials differences revealed in engineered bone as a function of cell-specific differentiation
E Gentleman, RJ Swain, ND Evans… - Nature materials, 2009 - nature.com
An important aim of regenerative medicine is to restore tissue function with implantable,
laboratory-grown constructs that contain tissue-specific cells that replicate the function of …
laboratory-grown constructs that contain tissue-specific cells that replicate the function of …
Small molecule mesengenic induction of human induced pluripotent stem cells to generate mesenchymal stem/stromal cells
YS Chen, RA Pelekanos, RL Ellis… - Stem cells …, 2012 - academic.oup.com
The translational potential of mesenchymal stem/stromal cells (MSCs) is limited by their
rarity in somatic organs, heterogeneity, and need for harvest by invasive procedures …
rarity in somatic organs, heterogeneity, and need for harvest by invasive procedures …
Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis
J Wu, D Song, Z Li, B Guo, Y Xiao, W Liu, L Liang… - Cell research, 2020 - nature.com
Lung injury and fibrosis represent the most significant outcomes of severe and acute lung
disorders, including COVID-19. However, there are still no effective drugs to treat lung injury …
disorders, including COVID-19. However, there are still no effective drugs to treat lung injury …