The immunotherapy of cancer has made significant strides in the past few years due to
improved understanding of the underlying principles of tumor biology and immunology …

The world is now experiencing an epidemic of obesity. Although the effects of obesity on the
development of metabolic and cardiovascular problems are well studied, much less is …

It is unclear why some SARS-CoV-2 patients readily resolve infection while others develop
severe disease. By interrogating metabolic programs of immune cells in severe and …

An important question in memory development is understanding the differences between
effector CD8 T cells that die versus effector cells that survive and give rise to memory cells …

DNA vaccines have evolved greatly over the last 20 years since their invention, but have yet
to become a competitive alternative to conventional protein or carbohydrate based human …

Abstract The Centers for Disease Control and Prevention has suggested that obesity may be
an independent risk factor for increased severity of illness from the H1N1 pandemic strain …

CD8+ T cells (also called cytotoxic T lymphocytes) play a major role in protective immunity
against many infectious pathogens and can eradicate malignant cells. The path from naive …

Previous research into the molecular mechanisms that underlie Ag-specific CD8+ T cell
differentiation and function has largely focused on the role of proteins. However, it is now …

Epigenetics can be defined as all the meiotically and mitotically inherited changes in gene
expression that are not encoded in the DNA sequence itself. Epigenetic modifications of …

Inflammation is a beneficial response of the body in response to external stimuli, while the
overwhelming inflammation caused by disease therapy often leads to treatment failure …