[HTML][HTML] A glance through the effects of CD4+ T cells, CD8+ T cells, and cytokines on Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia. Unfortunately, despite
numerous studies, an effective treatment for AD has not yet been established. There is …
numerous studies, an effective treatment for AD has not yet been established. There is …
Impact of inflammation and Treg cell regulation on neuropathic pain in spinal cord injury: mechanisms and therapeutic prospects
C Zhang, Y Li, Y Yu, Z Li, X Xu, Z Talifu, W Liu… - Frontiers in …, 2024 - frontiersin.org
Spinal cord injury is a severe neurological trauma that can frequently lead to neuropathic
pain. During the initial stages following spinal cord injury, inflammation plays a critical role; …
pain. During the initial stages following spinal cord injury, inflammation plays a critical role; …
[HTML][HTML] Inflammation, autoimmunity and neurodegenerative diseases, therapeutics and beyond
JV Garmendia, CV De Sanctis, V Das… - Current …, 2024 - ncbi.nlm.nih.gov
Neurodegenerative disease (ND) incidence has recently increased due to improved life
expectancy. Alzheimer's (AD) or Parkinson's disease (PD) are the most prevalent NDs. Both …
expectancy. Alzheimer's (AD) or Parkinson's disease (PD) are the most prevalent NDs. Both …
Glucose competition between endothelial cells in the blood-spinal cord barrier and infiltrating regulatory T cells is linked to sleep restriction-induced hyperalgesia
Y Huang, R Xu, Q Liu, X Zhang, Y Mao, Y Yang, X Gu… - BMC medicine, 2024 - Springer
Background Sleep loss is a common public health problem that causes hyperalgesia,
especially that after surgery, which reduces the quality of life seriously. Methods The 48-h …
especially that after surgery, which reduces the quality of life seriously. Methods The 48-h …
CASP8 is a potential therapeutic target and is correlated with pyroptosis in traumatic brain injury
G Zhao, Y Fu, C Yang, X Yang, X Hu - World Neurosurgery, 2023 - Elsevier
Background Traumatic brain injury (TBI) is a major cause of neurological and psychological
problems, especially long-term disability. The purpose of this article is to explore molecular …
problems, especially long-term disability. The purpose of this article is to explore molecular …
Regulatory T lymphocytes in traumatic brain injury
J Shan, R Shi, R Hazra, X Hu - Neurochemistry International, 2023 - Elsevier
Traumatic brain injury (TBI) presents a significant global health challenge with no effective
therapies developed to date. Regulatory T lymphocytes (Tregs) have recently emerged as a …
therapies developed to date. Regulatory T lymphocytes (Tregs) have recently emerged as a …
Cerebroprotective Effects of the TLR4-Binding DNA Aptamer ApTOLL in a Rat Model of Ischemic Stroke and Thrombectomy Recanalization
A Aliena-Valero, M Hernández-Jiménez… - Pharmaceutics, 2024 - mdpi.com
ApTOLL, a TLR4 modulator aptamer, has demonstrated cerebroprotective effects in a
permanent ischemic stroke mouse model, as well as safety and efficacy in early phase …
permanent ischemic stroke mouse model, as well as safety and efficacy in early phase …
Therapeutic opportunities for regulatory T-cell enhancing approaches
DF Tough, G Lombardi - Clinical and Experimental Immunology, 2023 - academic.oup.com
The immune system plays a critical role in protecting the host against infection but is subject
to numerous levels of control that are necessary to prevent pathological, tissue-damaging …
to numerous levels of control that are necessary to prevent pathological, tissue-damaging …
The association of microbial infection and adaptive immune cell activation in Alzheimer's disease
M Clement - Discovery Immunology, 2023 - academic.oup.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common form of dementia. Early symptoms include the loss of memory and mild cognitive …
common form of dementia. Early symptoms include the loss of memory and mild cognitive …
Modeling gene-environment interactions in Parkinson's Disease: Helicobacter pylori infection of Pink1-/-mice induces CD8 T cell-dependent motor and cognitive …
A Kazanova, J Sung, NL Oliveira, C Gavino… - bioRxiv, 2024 - biorxiv.org
Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by
progressive loss of motor function. Diagnosis occurs late: after motor symptom development …
progressive loss of motor function. Diagnosis occurs late: after motor symptom development …