[HTML][HTML] A glance through the effects of CD4+ T cells, CD8+ T cells, and cytokines on Alzheimer's disease

A Afsar, M Chen, Z Xuan, L Zhang - Computational and Structural …, 2023 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia. Unfortunately, despite
numerous studies, an effective treatment for AD has not yet been established. There is …

Impact of inflammation and Treg cell regulation on neuropathic pain in spinal cord injury: mechanisms and therapeutic prospects

C Zhang, Y Li, Y Yu, Z Li, X Xu, Z Talifu, W Liu… - Frontiers in …, 2024 - frontiersin.org
Spinal cord injury is a severe neurological trauma that can frequently lead to neuropathic
pain. During the initial stages following spinal cord injury, inflammation plays a critical role; …

[HTML][HTML] Inflammation, autoimmunity and neurodegenerative diseases, therapeutics and beyond

JV Garmendia, CV De Sanctis, V Das… - Current …, 2024 - ncbi.nlm.nih.gov
Neurodegenerative disease (ND) incidence has recently increased due to improved life
expectancy. Alzheimer's (AD) or Parkinson's disease (PD) are the most prevalent NDs. Both …

Glucose competition between endothelial cells in the blood-spinal cord barrier and infiltrating regulatory T cells is linked to sleep restriction-induced hyperalgesia

Y Huang, R Xu, Q Liu, X Zhang, Y Mao, Y Yang, X Gu… - BMC medicine, 2024 - Springer
Background Sleep loss is a common public health problem that causes hyperalgesia,
especially that after surgery, which reduces the quality of life seriously. Methods The 48-h …

CASP8 is a potential therapeutic target and is correlated with pyroptosis in traumatic brain injury

G Zhao, Y Fu, C Yang, X Yang, X Hu - World Neurosurgery, 2023 - Elsevier
Background Traumatic brain injury (TBI) is a major cause of neurological and psychological
problems, especially long-term disability. The purpose of this article is to explore molecular …

Regulatory T lymphocytes in traumatic brain injury

J Shan, R Shi, R Hazra, X Hu - Neurochemistry International, 2023 - Elsevier
Traumatic brain injury (TBI) presents a significant global health challenge with no effective
therapies developed to date. Regulatory T lymphocytes (Tregs) have recently emerged as a …

Cerebroprotective Effects of the TLR4-Binding DNA Aptamer ApTOLL in a Rat Model of Ischemic Stroke and Thrombectomy Recanalization

A Aliena-Valero, M Hernández-Jiménez… - Pharmaceutics, 2024 - mdpi.com
ApTOLL, a TLR4 modulator aptamer, has demonstrated cerebroprotective effects in a
permanent ischemic stroke mouse model, as well as safety and efficacy in early phase …

Therapeutic opportunities for regulatory T-cell enhancing approaches

DF Tough, G Lombardi - Clinical and Experimental Immunology, 2023 - academic.oup.com
The immune system plays a critical role in protecting the host against infection but is subject
to numerous levels of control that are necessary to prevent pathological, tissue-damaging …

The association of microbial infection and adaptive immune cell activation in Alzheimer's disease

M Clement - Discovery Immunology, 2023 - academic.oup.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common form of dementia. Early symptoms include the loss of memory and mild cognitive …

Modeling gene-environment interactions in Parkinson's Disease: Helicobacter pylori infection of Pink1-/-mice induces CD8 T cell-dependent motor and cognitive …

A Kazanova, J Sung, NL Oliveira, C Gavino… - bioRxiv, 2024 - biorxiv.org
Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by
progressive loss of motor function. Diagnosis occurs late: after motor symptom development …