The influence of subcortical shortcuts on disordered sensory and cognitive processing

J McFadyen, RJ Dolan, MI Garrido - Nature Reviews Neuroscience, 2020 - nature.com
The very earliest stages of sensory processing have the potential to alter how we perceive
and respond to our environment. These initial processing circuits can incorporate subcortical …

The superior colliculus: cell types, connectivity, and behavior

X Liu, H Huang, TP Snutch, P Cao, L Wang… - Neuroscience Bulletin, 2022 - Springer
The superior colliculus (SC), one of the most well-characterized midbrain sensorimotor
structures where visual, auditory, and somatosensory information are integrated to initiate …

Paraventricular nucleus CRH neurons encode stress controllability and regulate defensive behavior selection

N Daviu, T Füzesi, DG Rosenegger, NP Rasiah… - Nature …, 2020 - nature.com
In humans and rodents, the perception of control during stressful events has lasting
behavioral consequences. These consequences are apparent even in situations that are …

An afferent white matter pathway from the pulvinar to the amygdala facilitates fear recognition

J McFadyen, JB Mattingley, MI Garrido - elife, 2019 - elifesciences.org
Our ability to rapidly detect threats is thought to be subserved by a subcortical pathway that
quickly conveys visual information to the amygdala. This neural shortcut has been …

Investigating the subcortical route to the amygdala across species and in disordered fear responses

J McFadyen - Journal of Experimental Neuroscience, 2019 - journals.sagepub.com
Over the past few decades, evidence has come to light that there is a rapid subcortical
shortcut that transmits visual information to the amygdala, effectively bypassing the visual …

The “primitive brain dysfunction” theory of autism: the superior colliculus role

R Jure - Frontiers in Integrative Neuroscience, 2022 - frontiersin.org
A better understanding of the pathogenesis of autism will help clarify our conception of the
complexity of normal brain development. The crucial deficit may lie in the postnatal changes …

Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 …

LE Burnett, P Koppensteiner, O Symonova… - PLoS …, 2024 - journals.plos.org
Despite the diverse genetic origins of autism spectrum disorders (ASDs), affected individuals
share strikingly similar and correlated behavioural traits that include perceptual and sensory …

A Non-canonical Excitatory PV RGC–PV SC Visual Pathway for Mediating the Looming-evoked Innate Defensive Response

M Yuan, S Jin, G Tan, S Song, Y Liu, H Wang… - Neuroscience …, 2024 - Springer
Parvalbumin-positive retinal ganglion cells (PV+ RGCs) are an essential subset of RGCs
found in various species. However, their role in transmitting visual information remains …

GABAergic Retinal Ganglion Cells Projecting to the Superior Colliculus Mediate the Looming-Evoked Flight Response

M Yuan, G Tan, D Cai, X Luo, K Shen, Q Deng… - Neuroscience …, 2024 - Springer
The looming stimulus-evoked flight response to approaching predators is a defensive
behavior in most animals. However, how looming stimuli are detected in the retina and …

Subcortical circuit dysfunctions delay perceptual decision-making in autism models

LE Burnett, P Koppensteiner, O Symonova, T Masson… - bioRxiv, 2022 - biorxiv.org
Autism spectrum disorders (ASD) include a range of neurodevelopmental conditions
characterised by social and communication difficulties, often co-occurring with sensory …