Irisin is a hormone-like molecule mainly released by skeletal muscles in response to
exercise. Irisin induces browning of the white adipose tissue and has been shown to …

Although the chemotherapeutic drug, doxorubicin, is commonly used to treat various
malignant tumors, its clinical use is restricted because of its toxicity especially cardiotoxicity …

Radio-and chemotherapy are the most common cancer treatment modalities. They cause
acute and late side effects on normal tissues, which is a burden for delivery of a high dose of …

Ovarian damage and fertility impairment are major side effects of chemotherapy in pre-
menopausal cancer patients. Cisplatin is a widely used chemotherapeutic drug. The present …

There is growing concern that chemotherapy drugs can damage Leydig cells and inhibit the
production of testosterone. Increasing evidence shows that melatonin benefits the …

Radiotherapy and chemotherapy are two famous modalities in tumor‐targeted therapy that
lead to systemic and local toxicities for normal tissues. Moreover, several studies have …

Abstract Purpose 5-fluorouracil (5-FU), an effective chemotherapy drug, is commonly
applied for colorectal cancer treatment. Nevertheless, its toxicity to normal tissues and the …

Purpose Doxorubicin, as an effective chemotherapeutic drug, is commonly used for
combating various solid and hematological tumors. However, doxorubicin-induced …

Melatonin has the ability to intervene in the initiation, progression and metastasis of some
experimental cancers. A large variety of potential mechanisms have been advanced to …

Berberine (BBR) is a natural compound of plant origin belonging to isoquinoline type of
alkaloid. Methotrexate (MTX) is an anti-metabolite used widely for a variety of tumors and …