ABSTRACT Introduction: St. John's wort (SJW) is a common medicinal herb used for the
treatment of mild to moderate depression. Hyperforin, one of the chief components of SJW …

Drug‐drug interaction (DDI) is a common clinical problem that has occurred as a result of the
concomitant use of multiple drugs. DDI may occur in patients under treatment with …

Drug pharmacokinetics (PK) is influenced by multiple intrinsic and extrinsic factors, among
which concomitant medications are responsible for drug–drug interactions (DDIs) that may …

Owing to the improved longevity afforded by combination antiretroviral therapy (cART), HIV-
infected individuals are developing several non-AIDS-related comorbid conditions …

In this research, a metal-free diastereoselective formal 1, 3-dipolar cycloaddition of N-2, 2, 2-
trifluoroethylisatin ketimines and cyclopentene-1, 3-diones which can efficiently lead to the …

The drug–drug interaction studies for HCV direct-acting antivirals and antiretrovirals are
important in determining the appropriate drug combinations and dosages. The clinical …

Drug–drug interactions (DDIs) related to altered drug absorption and plasma protein binding
have received much less attention from regulatory agencies relative to DDIs mediated via …

Sofosbuvir has demonstrated several advantages over the traditional anti-hepatitis C (HCV)
therapies; however, it has been found susceptible to hydrolysis and has a risk of hepatic …

HCV infection is a major cause of mortality worldwide. HCV-related deaths also represent a
leading cause of mortality in HIV-coinfected individuals. Telaprevir is an NS3/4A protease …

Ribavirin, a guanosine analog, is a broad-spectrum antiviral agent. Ribavirin has been a
fundamental component of the treatment of hepatitis C virus (HCV) infection for decades, but …