Life-course epidemiologists have developed sophisticated models for how exposures
throughout life—from gestation to old age—shape health, sometimes years after the …

Recently, biological aging has been quantified in DNA-methylation samples of older adults
and applied as so-called “methylation profile scores”(MPSs) in separate target samples …

Disruptive events such as economic recessions, natural disasters, job loss, and divorce are
highly prevalent among American families. These events can have a long-lasting impact …

The goal of this study is to examine the association between in utero drought exposure and
epigenetic age acceleration (EAA) in a global climate change hot spot. Calculations of EAA …

Importance Children who are socioeconomically disadvantaged are at increased risk for
high body mass index (BMI) and multiple diseases in adulthood. The developmental origins …

In this article, we suggest that aging and development are two sides of the same coin, and
that developing a comprehensive understanding of health and disease risk requires …

Human fetal development has been associated with brain health at later stages. It is
unknown whether growth in utero, as indexed by birth weight (BW), relates consistently to …

This paper studies the long-run mortality effects of in utero and early-life economic
conditions. We examine how local economic conditions experienced during the Great …

To test the hypothesis that early-life adversity accelerates the pace of biological aging, we
analyzed data from the Dutch Hunger Winter Families Study (DHWFS, N= 951). DHWFS is a …

Biological aging is the correlated decline of multi-organ system integrity central to the
etiology of many age-related diseases. A novel epigenetic measure of biological aging …