Translating cough mechanisms into better cough suppressants

JA Keller, AE McGovern, SB Mazzone - Chest, 2017 - Elsevier
Chronic cough is a significant problem, and in many patients cough remains refractive to
both disease-specific therapies and current cough-suppressing medicines, creating a need …

Chronic cough in adults: make the diagnosis and make a difference

AG Kaplan - Pulmonary Therapy, 2019 - Springer
Chronic cough is common and impactful, frustrating both patients and clinicians. An
empirical trial of therapy is often done with inhaled corticosteroids, but this practice should …

BLU-5937: a selective P2X3 antagonist with potent anti-tussive effect and no taste alteration

D Garceau, N Chauret - Pulmonary pharmacology & therapeutics, 2019 - Elsevier
BLU-5937 is a small molecule that was shown to be a potent, selective and non-competitive
P2X3 homotrimeric receptor antagonist. P2X3 receptors are ATP ion-gated channels located …

[HTML][HTML] Prevalence and incidence of, and risk factors for chronic cough in the adult population: the Rotterdam Study

JT Arinze, EW de Roos, L Karimi… - ERJ open …, 2020 - Eur Respiratory Soc
Chronic cough is a common complaint in the general population but there are no precise
data on the incidence of, and prospectively examined risk factors for chronic cough in a …

Prevalence of cough throughout childhood: a cohort study

M Jurca, A Ramette, CM Dogaru, M Goutaki… - PLoS …, 2017 - journals.plos.org
Background Cough in children is a common reason for medical consultations and affects
quality of life. There are little population-based data on the epidemiology of recurrent cough …

[HTML][HTML] Leitlinie der deutschen gesellschaft für pneumologie und beatmungsmedizin zur diagnostik und therapie von erwachsenen patienten mit husten

P Kardos, QT Dinh, KH Fuchs, A Gillissen… - …, 2019 - thieme-connect.com
Die vorliegende 2019 S2k-Leitlinie der DGP wurde im Gegensatz zu den S3-Vorgänger-
Leitlinien aus dem Jahre 2004 und 2010 für Pneumologen verfasst, für Allgemeinärzte liegt …

[HTML][HTML] Upper airway cough syndrome in pathogenesis of chronic cough

M Lucanska, A Hajtman, V Calkovsky, K Peter… - Physiological …, 2020 - ncbi.nlm.nih.gov
Cough is one of the most important defensive reflexes. However, extensive non-productive
cough is a harmful mechanism leading to the damage of human airways. Cough is initiated …

Chronic cough as a female gender issue

N Kavalcikova-Bogdanova, T Buday, J Plevkova… - Respiratory …, 2016 - Springer
Cough accompanying acute respiratory tract disorders is a self-limiting phenomenon, and it
usually does not require sophisticated management. Chronic cough, in contrast, is a …

[HTML][HTML] Female guinea pig model for cough studies and its response to most common tussive substances

M Sterusky, J Plevkova, M Grendar… - Physiological …, 2020 - ncbi.nlm.nih.gov
Laboratory research of cough reflex utilizes almost exclusively male guinea pigs–a practice
that represents a significant obstacle in the successful translation of results into clinical …

[PDF][PDF] Exhaled nitric oxide in patients with stable chronic obstructive pulmonary disease: clinical implications of the use of inhaled corticosteroids

BW Jhun, WJ Koh, TJ An, JW Kim… - Tuberculosis and …, 2020 - synapse.koreamed.org
Tuberculosis (TB) remains a threat to public health and is the leading cause of death
globally. Isoniazid (INH) is an important first-line agent for the treatment of TB considering its …