Airway inflammation in severe asthma is not well characterized but may involve neutrophils.
We have compared induced sputum profiles in patients with asthma of varying severity and …

I. Introduction S TEROID hormones are essential constituents of the intercellular
communication system that maintains homeostasis in higher organisms. Glucocorticoids, a …

In the mid-1980s, Mosmann, Coffman, and their colleagues discovered that murine CD4+
helper T-cell clones could be distinguished by the cytokines they synthesized. The isolation …

Glucocorticoids continue to be the ma‐jor immunomodulatory agents used in clinical
medicine today. However, their actions as anti‐inflammatory and immunosuppressive drugs …

IgE plays an important role in allergic asthma. We hypothesized that reducing IgE in the
airway mucosa would reduce airway inflammation. Forty-five patients with mild to moderate …

Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …

Continuing Medical Education examination CONTINUING MEDICAL EDUCATION
ARTICLECredit can now be obtained, free for a limited time, by reading the following review …

Glucocorticoids are the most effective anti-inflammatory therapy for many chronic
inflammatory and immune diseases, such as asthma, but are relatively ineffective in other …

Cytokines are usually extracellular signalling proteins, usually less than 80 kD in size, and
many are glycosylated. They are produced by many diVerent cell types that are involved in …

In order to investigate the relationship between airways inflammation and disease severity,
and improve the understanding of persistent asthma, 74 asthmatics, with disease severity …