Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …

Tissue-resident immune cells span both myeloid and lymphoid cell lineages, have been
found in multiple human tissues, and play integral roles at all stages of the immune …

HIV-associated cryptococcal meningitis is by far the most common cause of adult meningitis
in many areas of the world that have high HIV seroprevalence. In most areas in Sub …

Despite accumulating evidence suggesting local self-maintenance of tissue macrophages in
the steady state, the dogma remains that tissue macrophages derive from monocytes. Using …

Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …

Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines
underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare …

Haploinsufficiency of the hematopoietic transcription factor GATA2 underlies monocytopenia
and mycobacterial infections; dendritic cell, monocyte, B, and natural killer (NK) lymphoid …

Despite its complexity, blood is probably the best understood developmental system, largely
due to seminal experimentation in the mouse. Clinically, hematopoietic stem cell (HSC) …

Natural killer (NK) cells are part of the innate immune defense against infection and cancer
and are especially useful in combating certain viral pathogens. The utility of NK cells in …

Abstract Type 1 diabetes (T1D) is an autoimmune disease characterised by multiple defects
of immune cells which allow the expansion of pathogenic β cell-specific T effector cells and …