Adaptive immunity

FA Bonilla, HC Oettgen - Journal of Allergy and Clinical Immunology, 2010 - Elsevier
The innate immune system provides critical mechanisms for the rapid sensing and
elimination of pathogens. Adaptive immunity has evolved to provide a broader and more …

The genetics and epigenetics of atopic dermatitis—filaggrin and other polymorphisms

Y Liang, C Chang, Q Lu - Clinical reviews in allergy & immunology, 2016 - Springer
Atopic dermatitis (AD) is a chronic inflammatory skin disease caused by a combination of
genetic and environmental factors. Genetic evidences depict a complex network comprising …

Genetic and epigenetic aspects of atopic dermatitis

B Nedoszytko, E Reszka, D Gutowska-Owsiak… - International journal of …, 2020 - mdpi.com
Atopic dermatitis is a heterogeneous disease, in which the pathogenesis is associated with
mutations in genes encoding epidermal structural proteins, barrier enzymes, and their …

Both inflammatory and regulatory cytokine responses to malaria are blunted with increasing age in highly exposed children

L Farrington, H Vance, J Rek, M Prahl, P Jagannathan… - Malaria journal, 2017 - Springer
Background Young children are at greatest risk for malaria-associated morbidity and
mortality. The immune response of young children differs in fundamental ways from that of …

The association between diabetes and obesity with Dengue infections

SD Sekaran, ZM Liew, HC Yam, CS Raju - Diabetology & Metabolic …, 2022 - Springer
Dengue, an arboviral disease is a global threat to public health as the number of Dengue
cases increases through the decades and this trend is predicted to continue. Non …

In utero priming of highly functional effector T cell responses to human malaria

PM Odorizzi, P Jagannathan, TI McIntyre… - Science translational …, 2018 - science.org
Malaria remains a significant cause of morbidity and mortality worldwide, particularly in
infants and children. Some studies have reported that exposure to malaria antigens in utero …

Genomic, Epigenomic, Transcriptomic, Proteomic and Metabolomic Approaches in Atopic Dermatitis

D Bratu, D Boda, C Caruntu - Current Issues in Molecular Biology, 2023 - mdpi.com
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a high prevalence in the
developed countries. It is associated with atopic and non-atopic diseases, and its close …

Epigenetics in immune development and in allergic and autoimmune diseases

D Martino, DA Kesper, M Amarasekera, H Harb… - Journal of reproductive …, 2014 - Elsevier
Epigenetic mechanisms such as DNA methylation, histone modification, and micro RNA
signaling regulate the activity of the genome. Virtually all aspects of immunity involve some …

The association between IFN-γ and IL-4 genetic polymorphisms and childhood susceptibility to bronchial asthma

HR Huang, YQ Zhong, JF Wu - Gene, 2012 - Elsevier
The present study aims to investigate the association between the genetic polymorphisms of
interferon (IFN)-γ and interleukin (IL)-4 with childhood susceptibility to asthma and the levels …

Identification of biomarker sets for predicting the efficacy of sublingual immunotherapy against pollen-induced allergic rhinitis

M Gotoh, O Kaminuma, A Nakaya… - International …, 2017 - academic.oup.com
Sublingual immunotherapy (SLIT) is effective against allergic rhinitis, although a substantial
proportion of individuals is refractory. Herein, we describe a predictive modality to reliably …