ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …

Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, provides a
potential treatment avenue for drug-resistant cancers and may play a role in the pathology of …

The growing knowledge of ferroptosis has suggested the role and therapeutic potential of
ferroptosis in cancer, but has not been translated into effective therapy. Liver cancer …

Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …

The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors.
Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid …

Ferroptosis and neuroinflammation play crucial roles in Alzheimer's disease (AD)
pathophysiology. Forsythoside A (FA), the main constituent of Forsythia suspensa (Thunb.) …

Hepatocellular carcinoma (HCC) is one of the paramount causes of cancer-related death
worldwide. Despite recent advances have been made in clinical treatments of HCC, the …

Ferroptosis is a recently discovered essential type of cell death that is mainly characterized
by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a …

Humans are inevitably exposed to ethyl carbamate (EC) via consumption of fermented food
and beverages. EC, known as an environmental toxin, can cause oxidative stress-mediated …