Sex steroids are chief regulators of gender differences in the skeleton, and male gender is
one of the strongest protective factors against osteoporotic fractures. This advantage in bone …

The androgen receptor (AR) signaling axis drives all stages of prostate cancer, including the
lethal, drug-resistant form of the disease termed castration-resistant prostate cancer (CRPC) …

Biological sex is a primary determinant of athletic performance because of fundamental sex
differences in anatomy and physiology dictated by sex chromosomes and sex hormones …

Abstract Romero-Parra, N, Cupeiro, R, Alfaro-Magallanes, VM, Rael, B, Rubio-Arias, JA,
Peinado, AB, and Benito, PJ, IronFEMME Study Group. Exercise-induced muscle damage …

Abstract Purpose of Review Cachexia, a feature of cancer and other chronic diseases, is
marked by progressive weight loss and skeletal muscle wasting. This review aims to …

Bone is a biomechanical tissue shaped by forces from muscles and gravitation.
Simultaneous bone and muscle decay and dysfunction (osteosarcopenia or sarco …

Only in recent years, thanks to a precision medicine-based approach, have treatments
tailored to the sex of each patient emerged in clinical trials. In this regard, both striated …

Purpose This study assessed markers of muscle damage and training adaptations to
eccentric-overload flywheel resistance exercise (RE) in men and women. Methods Dynamic …

Extreme or unaccustomed eccentric exercise can cause exercise-induced muscle damage,
characterized by structural changes involving sarcomere, cytoskeletal, and membrane …

Menopausal symptoms in women can be severe and disruptive to overall quality of life.
Hormone replacement therapy, is known to be effective in ameliorating symptoms, however …