The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

The decline of oxygen tension in the tissues below the physiological demand leads to the
hypoxic adaptive response. This physiological consequence enables cells to recover from …

HIF plays a central role in the transcriptional response to changes in oxygen availability. The
PHD family of oxygen-dependent prolyl hydroxylases plays a pivotal role in regulating HIF …

Hypoxia is a fundamental stimulus that impacts cells, tissues, organs, and physiological
systems. The discovery of hypoxia-inducible factor-1 (HIF-1) and subsequent identification of …

Transcriptional responses to hypoxia are primarily mediated by hypoxia-inducible factor
(HIF), a heterodimer of HIF-α and the aryl hydrocarbon receptor nuclear translocator …

A constant supply of oxygen is indispensable for cardiac viability and function. However, the
role of oxygen and oxygen-associated processes in the heart is complex, and they and can …

Hypoxia-inducible factor (HIF) controls an extensive range of adaptive responses to hypoxia.
To better understand this transcriptional cascade we performed genome-wide chromatin …

Defective function of the von Hippel-Lindau (VHL) tumor suppressor ablates proteolytic
regulation of hypoxia-inducible factor α subunits (HIF-1α and HIF-2α), leading to constitutive …

The ability to sense and respond to changes in oxygenation represents a fundamental
property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the …

All eukaryotic cells utilize oxidative phosphorylation to maintain their high‐energy
phosphate stores. Mitochondrial oxygen consumption is required for ATP generation, and …