Intrarenal oxygen availability is the balance between supply, mainly dependent on renal
blood flow, and demand, determined by the basal metabolic demand and the energy …

Angiogenesis in tumors is controlled by the so-called 'angiogenic switch'which allows the
passage from low invasive and poorly vascularized tumors to highly invasive and …

Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that directs a broad
range of cellular responses to hypoxia. Recent studies have defined a set of 2-oxoglutarate …

Differential regulation as well as target gene specificity of the two hypoxia-inducible factor
(HIF)-α subunits HIF-1α and HIF-2α in various tumors and cell lines have been suggested. In …

Hypoxia, or lowered physiological oxygenation, is a component of many diseases. The
response to decreased oxygen tensions is also an essential aspect of normal development …

Glioblastoma (GBM) prognosis remains dismal, with most patients succumbing to disease
within 1 or 2 years of diagnosis. Recent studies have suggested that many solid tumors …

Hypoxia-inducible factors (HIFs) are transcription factors that reprogram the transcriptome
for cells to survive hypoxic insults and oxidative stress. They are important during embryonic …

Regulation of vascular endothelial growth factor (VEGF) expression is a complex process
involving a plethora of transcriptional regulators. The AP‐1 transcription factor is considered …

Hypoxia-inducible factor-1 (HIF-1) is a key regulator of the cellular hypoxic response. We
previously showed that HIF-1 activation is essential for heat acclimation (AC) in …

Objective We have previously demonstrated that the transcription factor hypoxia‐inducible
factor 1 (HIF‐1) promotes the onset of autophagy in chondrocytes. The overall goal of this …