Hypertension is closely associated with progressive kidney dysfunction, manifested as
glomerulosclerosis, interstitial fibrosis, proteinuria, and eventually declining glomerular …

Hypoxia is defined as a deficiency of oxygen reaching the tissues of the body, and it plays a
critical role in development and pathological conditions, such as cancer. Once tumors …

Purpose Up-regulation of pro-angiogenic cytokine expression occurring secondary to
hypoxia in physiologic and pathophysiologic conditions is mediated by the family of …

Tumor progression is intrinsically tied to the clonal selection of tumor cells with acquired
phenotypes allowing to cope with a hostile microenvironment. Hypoxia-inducible factors …

The hypoxia-inducible factor (HIF) is a key player in a transcriptional pathway that controls
the hypoxic response of mammalian cells. Post-translational modification of the α subunit of …

Background In human IVF, embryos cultured with a lower O 2 tension (5%) can give rise to
higher success rates when compared with normoxic conditions (20%). However, the …

Oxygen and reactive oxygen species (ROS), as indispensable small molecular substances
in the basic metabolism of life, have become the key to the success of implantable medical …

Background/Aims: Hypoxia is a powerful stimulator of angiogenesis under physiological as
well as pathological conditions. Normal endothelial cells (EC), such as human umbilical vein …

Hypoxia-inducible factors (HIFs) are transcriptional regulators that mediate the cellular
response to low oxygen. Although HIF-1 is usually considered as the principal mediator of …

Simple Summary Thoraco-abdominal paraganglioma and pheochromocytoma (PPGL) are
pathogenically linked to mutations in SDH genes. Loss-of-function of SDH has been …