The unfolded protein response (UPR) is a conserved adaptive pathway that helps cells cope
with the protein misfolding burden within the endoplasmic reticulum (ER). Imbalance …

Rationale: In the bone marrow microenvironment (BMME), mesenchymal stem/stromal cells
(MSCs) control the self-renewal of both healthy and cancerous hematopoietic …

Gap junctions (GJs)-mediated intercellular communications (GJICs) are connexin (Cx)-
formed plasma membrane channels that allow for the passage of small molecules between …

GN refers to a variety of renal pathologies that often progress to ESRD, but the molecular
mechanisms underlying this progression remain incompletely characterized. Here, we …

Wound healing can be divided into different phases, and timely initiation and cessation of
these stages is key to successful wound healing; otherwise, scar tissue forms in the …

The crosstalk between hematopoietic stem cells (HSC) and bone marrow (BM)
microenvironment is critical for homeostasis and hematopoietic regeneration in response to …

The tumor microenvironment is known to have increased levels of cytokines and
metabolites, such as glutamate, due to their release from the surrounding cells. A normal cell …

The tumor microenvironment (TME) not only plays a pivotal role during cancer progression
and metastasis, but also has profound effects on therapeutic efficacy. Stromal cells of the …

Connexins are a family of gap junction proteins widely distributed in human organs and
tissues. Gap junctions are organized systems of intercellular protein channels that allow the …

Cell death is a fundamental process for organogenesis, immunity and cell renewal. During
the last decades a broad range of molecular tools were identified as important players for …