To improve prognosis in recurrent glioblastoma we developed a treatment protocol based
on a combination of drugs not traditionally thought of as cytotoxic chemotherapy agents but …

Glioblastoma multiforme (GBM) is the most malignant primary adult brain tumor. The current
standard of care is surgical resection, radiation, and chemotherapy treatment, which extends …

The associations of tricyclic antidepressants (TCAs) with reduced incidence of gliomas and
elevated autophagy in glioma cells motivated investigation in mouse models of …

Neither pain, nor depression exist as independent phenomena per se, they are highly
subjective inner states, formed by our brain and built on the bases of our experiences …

Background and Purpose: Drug repositioning is a promising strategy for discovering new
therapeutic strategies for cancer therapy. We investigated psychotropic drugs for their …

Depression is one of the leading causes of global disability, and a considerable hidden
morbidity among patients with glioma. In this narrative review, we summarise what is …

Background: Depression and anxiety are common in cancer and antidepressants (AD) are
efficacious treatment. The relationship between AD adherence and mortality in cancer is …

Autophagy, a self-digestion intracellular catabolic process, plays a crucial role in cellular
homeostasis under conditions of starvation, oxidative stress and genotoxic stress. The …

In patients with gliomas, depression is a common complication that may cause severe
psychological barriers and deteriorate the patient's quality of life (QoL). Currently, the …

Glioblastoma is a brain neoplasm with limited 5‐year survival rates. Developments of new
treatment regimens that improve patient survival in patients with glioblastoma are needed. It …