Perturbations in cardiac energy metabolism are major contributors to a number of
cardiovascular pathologies. In addition, comorbidities associated with cardiovascular …

The alterations in myocardial energy substrate metabolism that occur in heart failure, and
the causes and consequences of these abnormalities, are poorly understood. There is …

The term “energy metabolism” used to be synonymous with the term “biochemistry of the
heart.” It refers to the large number of interconnected, enzyme-catalyzed reactions …

Emerging metabolomic tools have created the opportunity to establish metabolic signatures
of myocardial injury. We applied a mass spectrometry–based metabolite profiling platform to …

Background. The maintenance of cellular levels of high-energy phosphates is required for
myocardial function and preservation. In animals, severe myocardial ischemia is …

The human heart in the fasting state extracts FFA, glucose, lactate, pyruvate, and ketone
bodies from the systemic circulation. Of these substrates, FFA utilization accounts for the …

To evaluate acquired immunodeficiency syndrome (AIDS) in central Africa a prospective
study was done in Kigali, Rwanda, where Kaposi's sarcoma (KS) is endemic. During a 4 …

The rapid growth of cancer cells is permitted by metabolic changes, notably increased
aerobic glycolysis and increased glutaminolysis. Aerobic glycolysis is also evident in the …

The ability of coronary endothelial cells in 14 day confluent cultures to metabolize glucose,
palmitate, lactate and various amino acids was investigated. Under aerobic conditions, 99 …

In oxygen-deprived heart muscle tissue, alanine levels increase, whereas levels of
glutamate and aspartate decline, and it is therefore postulated that free tissue amino acids …