White matter occupies almost half of the human brain. It contains axons connecting spatially
segregated modules and, as such, it is essential for the smooth flow of information in …

Professor Derek Jones, a world authority on diffusion MRI, has assembled most of the
world's leading scientists and clinicians developing and applying diffusion MRI to produce …

Abstract Manganese ion (Mn2+) is a calcium (Ca2+) analog that can enter neurons and
other excitable cells through voltage gated Ca2+ channels. Mn2+ is also a paramagnetic …

Recent studies with magnetic resonance imaging suggest that age-related changes in white
matter during male adolescence may indicate an increase in g ratio wherein the radial …

Leber hereditary optic neuropathy (LHON) is a mitochondrially inherited form of visual
dysfunction caused by mutations in several genes encoding subunits of the mitochondrial …

The toxicity of the class of chemicals known as the organophosphates (OP) is most
commonly attributed to the inhibition of the enzyme acetylcholinesterase. However, there is …

There are two ways to picture white matter: as a grid of electrical wires or a network of roads.
The first metaphor captures the classical function of an axon as conductor of action …

Glaucoma is a neurodegenerative disease of the visual system. While elevated intraocular
pressure is considered to be a major risk factor, the primary cause and pathogenesis of the …

Purpose To provide dose‐response data for the safe and effective use of MnCl2 for
manganese (Mn2+)‐enhanced MRI (MEMRI) of the visual pathway. Materials and Methods …

Object To investigate the potential of a clinical 3 T scanner to perform MRI of small rodents.
Materials and methods Different dedicated small animal coils and several imaging …