Catheter-associated Mycobacterium intracellulare biofilm infection in C3HeB/FeJ mice
K Yamamoto, Y Tsujimura, M Ato - Scientific Reports, 2023 - nature.com
Non-tuberculosis mycobacterial (NTM) diseases are steadily increasing in prevalence and
mortality worldwide. Mycobacterium avium and M. intracellulare, the two major pathogens of …
mortality worldwide. Mycobacterium avium and M. intracellulare, the two major pathogens of …
Pathogen-derived nucleases: An effective weapon for escaping extracellular traps
C Liao, F Mao, M Qian, X Wang - Frontiers in Immunology, 2022 - frontiersin.org
Since the 2004 publication of the first study describing extracellular traps (ETs) from human
neutrophils, several reports have shown the presence of ETs in a variety of different animals …
neutrophils, several reports have shown the presence of ETs in a variety of different animals …
Napthalimide-based nuclease inhibitor: A multifunctional therapeutic material to bolster MRSA uptake by macrophage-like cells and mitigate pathogen adhesion on …
The healthcare burden rendered by methicillin-resistant Staphylococcus aureus (MRSA)
warrants the development of therapeutics that offer a distinct benefit in the clinics as …
warrants the development of therapeutics that offer a distinct benefit in the clinics as …
Micrococcal nuclease regulates biofilm formation and dispersal in methicillin-resistant Staphylococcus aureus USA300
JB Kaplan, AR Horswill - Msphere, 2024 - Am Soc Microbiol
Biofilm formation is an important virulence factor for methicillin-resistant Staphylococcus
aureus (MRSA). The extracellular matrix of MRSA biofilms contains significant amounts of …
aureus (MRSA). The extracellular matrix of MRSA biofilms contains significant amounts of …
Inhibition of staphylococcal nuclease by benzimidazole-based Ligand: Implications in DNA-Mediated entrapment and uptake of MRSA by Macrophage-like cells
The staphylococcal nuclease also referred as micrococcal nuclease (MNase) is a key drug
target as the enzyme degrades the neutrophil extracellular trap (NET) and empowers the …
target as the enzyme degrades the neutrophil extracellular trap (NET) and empowers the …
Anthraquinone‐Based Ligands as MNase Inhibitors: Insights from Inhibition Studies and Generation of a Payload Nanocarrier for Potential Anti‐MRSA Therapy
The present study highlights the prospect of an anthraquinone‐based ligand (C1) as an
inhibitor of micrococcal nuclease (MNase) enzyme secreted by Staphylococcus aureus …
inhibitor of micrococcal nuclease (MNase) enzyme secreted by Staphylococcus aureus …
Induction and Evasion of Neutrophil Extracellular Traps by Campylobacter jejuni and its Implication in Disease
SM Callahan - 2023 - trace.tennessee.edu
Campylobacteriosis, the foodborne disease caused by Campylobacter spp., infects one out
of 10 individuals every year. C. jejuni accounts for 90% of these infections resulting in …
of 10 individuals every year. C. jejuni accounts for 90% of these infections resulting in …
Identification of potential vaccine targets in livestock-associated Staphylococcus aureus
EV Murguia - 2023 - research.rug.nl
Mastitis, an infection of the mammary glands, is a common livestock disease. The bacterium
Staphylococcus aureus is the principal cause of mastitis. Bovine mastitis results in large …
Staphylococcus aureus is the principal cause of mastitis. Bovine mastitis results in large …