Potential mechanisms of target-independent uptake and toxicity of antibody-drug conjugates
PK Mahalingaiah, R Ciurlionis, KR Durbin… - Pharmacology & …, 2019 - Elsevier
Antibody-drug conjugates (ADCs) are a promising therapeutic modality for oncology
indications. The concept of an ADC platform is to increase the therapeutic index (TI) of …
indications. The concept of an ADC platform is to increase the therapeutic index (TI) of …
Advances in the understanding of the Fc gamma receptors-mediated autoantibodies uptake
Receptors for the Fc fragment of immunoglobulin G (FcγRs) are important molecules not
only to mediate and control the effectors' functions of IgG antibodies, but they also control the …
only to mediate and control the effectors' functions of IgG antibodies, but they also control the …
Response of normal human keratinocytes to sulfur mustard: cytokine release
CM Arroyo, RJ Schafer, EM Kurt… - Journal of applied …, 2000 - Wiley Online Library
Cytokines play a major role in both acute and chronic inflammatory processes, including
those produced by sulfur mustard (2, 2′‐dichlorodiethyl sulfide, HD). This study describes …
those produced by sulfur mustard (2, 2′‐dichlorodiethyl sulfide, HD). This study describes …
[HTML][HTML] Pemphigus vulgaris autoantibodies induce apoptosis in HaCaT keratinocytes
B Pelacho, C Natal, A España, I Sanchez-Carpintero… - FEBS letters, 2004 - Elsevier
Pemphigus vulgaris (PV) is an autoimmune disease characterized by binding of IgG
autoantibodies to epidermal keratinocyte desmosomes. IgG autoantibodies obtained from a …
autoantibodies to epidermal keratinocyte desmosomes. IgG autoantibodies obtained from a …
Fcγ receptors mediate internalization of anti‐Ro and anti‐La autoantibodies from Sjögren's syndrome and apoptosis in human salivary gland cell line A‐253
Background: The presence of serum anti‐Ro and anti‐La autoantibodies directed against
the ribonucleoproteins Ro and La has been associated with Sjögren's syndrome (SS), an …
the ribonucleoproteins Ro and La has been associated with Sjögren's syndrome (SS), an …
Response of normal human keratinocytes to sulfur mustard (HD): cytokine release using a non-enzymatic detachment procedure
CM Arroyo, RJ Schafer, EM Kurt… - Human & …, 1999 - journals.sagepub.com
Cytokines play a major role in both acute and chronic inflammatory processes, including
those produced by sulfur mustard (HD). This study describes responses of normal human …
those produced by sulfur mustard (HD). This study describes responses of normal human …
The epidermis
EK Parkinson, WA Yeudall - Culture of epithelial cells, 2002 - Wiley Online Library
Various attempts at growing keratinocytes are given in an historical review, with emphasis
on the 3T3 feeder layer technique. Protocols are provided for the disaggregation of skin by …
on the 3T3 feeder layer technique. Protocols are provided for the disaggregation of skin by …
Ocular effects of sulfur mustard
Y Panahi, M Naderi, MA Zare… - Journal of Current …, 2013 - search.proquest.com
Purpose: To review current knowledge about ocular effects of sulfur mustard (SM) and the
associated histopathologic findings and clinical manifestations Methods: Literature review of …
associated histopathologic findings and clinical manifestations Methods: Literature review of …
Autoantigen Ro52 directly interacts with human IgG heavy chain in vivo in mammalian cells
YS Yang, MCW Yang, B Wang, JC Weissler - Molecular Immunology, 2000 - Elsevier
Previously, when we used in vivo yeast two-hybrid and in vitro protein–protein interaction
analyses, we demonstrated a direct interaction between autoantigen Ro52 and the human …
analyses, we demonstrated a direct interaction between autoantigen Ro52 and the human …
Suppression of sulfur mustard-increased IL-8 in human keratinocyte cell cultures by serine protease inhibitors: implications for toxicity and medical countermeasures
FM Cowan, CA Broomfield, WJ Smith - Cell biology and toxicology, 2002 - Springer
The toxicity of the chemical warfare blistering agent sulfur mustard (2, 2'-dichlorodiethyl
sulfide; SM) has been investigated for nearly a century; however, the toxicological …
sulfide; SM) has been investigated for nearly a century; however, the toxicological …