A national toxicology program systematic review of the evidence for long-term effects after acute exposure to sarin nerve agent
DA Jett, CA Sibrizzi, RB Blain, PA Hartman… - Critical reviews in …, 2020 - Taylor & Francis
Sarin is a highly toxic nerve agent that was developed for chemical warfare during World
War II and is used in present conflicts. Immediate effects of acute sarin exposure are …
War II and is used in present conflicts. Immediate effects of acute sarin exposure are …
Low neuronal metabolism during isoflurane-induced burst suppression is related to synaptic inhibition while neurovascular coupling and mitochondrial function …
Deep anaesthesia may impair neuronal, vascular and mitochondrial function facilitating
neurological complications, such as delirium and stroke. On the other hand, deep …
neurological complications, such as delirium and stroke. On the other hand, deep …
Febrile Seizures, Ongoing Epileptiform Activity, and the Resulting Long-term Consequences: Lessons from Animal Models
SA Harris, EE Gordon, KT Barrett, MH Scantlebury… - Pediatric Neurology, 2024 - Elsevier
Abstract Febrile seizures affect 2-14% of children. Prospective studies indicate that following
a relatively prolonged febrile seizure there are long-term consequences. While controlled …
a relatively prolonged febrile seizure there are long-term consequences. While controlled …
Sudden unexpected death in epilepsy is prevented by blocking postictal hypoxia
Epilepsy is at times a fatal disease. Sudden unexpected death in epilepsy (SUDEP) is the
leading cause of epilepsy-related mortality in people with intractable epilepsy and is defined …
leading cause of epilepsy-related mortality in people with intractable epilepsy and is defined …
Electrographic seizures and brain hyperoxia may be key etiological factors for postconcussive deficits
H Malik, MD Wolff, GC Teskey… - Journal of …, 2022 - journals.physiology.org
Repetitive mild traumatic brain injuries (RmTBIs) are increasingly recognized to have long-
term neurological sequelae in a significant proportion of patients. Individuals that have had …
term neurological sequelae in a significant proportion of patients. Individuals that have had …
Dynamic oxygen changes during status epilepticus and subsequent endogenous kindling
MD Wolff, JS Farrell, MH Scantlebury, GC Teskey - Epilepsia, 2020 - Wiley Online Library
Objective Brain tissue oxygen (partial oxygen pressure [pO2]) levels are tightly regulated to
stay within the normoxic zone, with deviations on either side resulting in impaired brain …
stay within the normoxic zone, with deviations on either side resulting in impaired brain …
Fiber photometry for monitoring cerebral oxygen saturation in freely-moving rodents
Hemodynamic parameters, such as tissue oxygen saturation and blood volume fraction, are
important markers of brain physiology. They are also widely used surrogate markers of …
important markers of brain physiology. They are also widely used surrogate markers of …
[PDF][PDF] Partial pressure of oxygen (PO2)
S Sharma, D Rawat - StatPearls, StatPearls, Treasure Island, FL …, 2019 - researchgate.net
Oxygenation of tissues is one of the most important processes that occur within the human
body. Without proper oxygenation of tissues, metabolic processes cannot function efficiently …
body. Without proper oxygenation of tissues, metabolic processes cannot function efficiently …
Febrile seizures lead to prolonged epileptiform activity and hyperoxia that when blocked prevents learning deficits
SA Harris, AG George, KT Barrett, MH Scantlebury… - …, 2022 - Wiley Online Library
Objective In adult brain tissue, oxygen levels typically remain in the normoxic zone, but
status epilepticus results in hyperoxia, whereas brief self‐terminating seizures lead to …
status epilepticus results in hyperoxia, whereas brief self‐terminating seizures lead to …
Quantitative T2 MRI is predictive of neurodegeneration following organophosphate exposure in a rat model
K Lee, S Bohnert, M Bouchard, C Vair, JS Farrell… - Scientific Reports, 2020 - nature.com
Organophosphorus compounds, such as chemical warfare nerve agents and pesticides, are
known to cause neurological damage. This study measured nerve agent-related …
known to cause neurological damage. This study measured nerve agent-related …