A national toxicology program systematic review of the evidence for long-term effects after acute exposure to sarin nerve agent

DA Jett, CA Sibrizzi, RB Blain, PA Hartman… - Critical reviews in …, 2020 - Taylor & Francis
Sarin is a highly toxic nerve agent that was developed for chemical warfare during World
War II and is used in present conflicts. Immediate effects of acute sarin exposure are …

Low neuronal metabolism during isoflurane-induced burst suppression is related to synaptic inhibition while neurovascular coupling and mitochondrial function …

N Berndt, R Kovács, K Schoknecht… - Journal of Cerebral …, 2021 - journals.sagepub.com
Deep anaesthesia may impair neuronal, vascular and mitochondrial function facilitating
neurological complications, such as delirium and stroke. On the other hand, deep …

Febrile Seizures, Ongoing Epileptiform Activity, and the Resulting Long-term Consequences: Lessons from Animal Models

SA Harris, EE Gordon, KT Barrett, MH Scantlebury… - Pediatric Neurology, 2024 - Elsevier
Abstract Febrile seizures affect 2-14% of children. Prospective studies indicate that following
a relatively prolonged febrile seizure there are long-term consequences. While controlled …

Sudden unexpected death in epilepsy is prevented by blocking postictal hypoxia

AG George, JS Farrell, R Colangeli, AK Wall… - …, 2023 - Elsevier
Epilepsy is at times a fatal disease. Sudden unexpected death in epilepsy (SUDEP) is the
leading cause of epilepsy-related mortality in people with intractable epilepsy and is defined …

Electrographic seizures and brain hyperoxia may be key etiological factors for postconcussive deficits

H Malik, MD Wolff, GC Teskey… - Journal of …, 2022 - journals.physiology.org
Repetitive mild traumatic brain injuries (RmTBIs) are increasingly recognized to have long-
term neurological sequelae in a significant proportion of patients. Individuals that have had …

Dynamic oxygen changes during status epilepticus and subsequent endogenous kindling

MD Wolff, JS Farrell, MH Scantlebury, GC Teskey - Epilepsia, 2020 - Wiley Online Library
Objective Brain tissue oxygen (partial oxygen pressure [pO2]) levels are tightly regulated to
stay within the normoxic zone, with deviations on either side resulting in impaired brain …

Fiber photometry for monitoring cerebral oxygen saturation in freely-moving rodents

L Yu, EMS Thurston, M Hashem, JF Dunn… - Biomedical Optics …, 2020 - opg.optica.org
Hemodynamic parameters, such as tissue oxygen saturation and blood volume fraction, are
important markers of brain physiology. They are also widely used surrogate markers of …

[PDF][PDF] Partial pressure of oxygen (PO2)

S Sharma, D Rawat - StatPearls, StatPearls, Treasure Island, FL …, 2019 - researchgate.net
Oxygenation of tissues is one of the most important processes that occur within the human
body. Without proper oxygenation of tissues, metabolic processes cannot function efficiently …

Febrile seizures lead to prolonged epileptiform activity and hyperoxia that when blocked prevents learning deficits

SA Harris, AG George, KT Barrett, MH Scantlebury… - …, 2022 - Wiley Online Library
Objective In adult brain tissue, oxygen levels typically remain in the normoxic zone, but
status epilepticus results in hyperoxia, whereas brief self‐terminating seizures lead to …

Quantitative T2 MRI is predictive of neurodegeneration following organophosphate exposure in a rat model

K Lee, S Bohnert, M Bouchard, C Vair, JS Farrell… - Scientific Reports, 2020 - nature.com
Organophosphorus compounds, such as chemical warfare nerve agents and pesticides, are
known to cause neurological damage. This study measured nerve agent-related …