Nucleophosmin in its interaction with ligands

I Cela, A Di Matteo, L Federici - International journal of molecular sciences, 2020 - mdpi.com
Nucleophosmin (NPM1) is a mainly nucleolar protein that shuttles between nucleoli,
nucleoplasm and cytoplasm to fulfill its many functions. It is a chaperone of both nucleic …

Nucleophosmin1 (NPM1) abnormality in hematologic malignancies, and therapeutic targeting of mutant NPM1 in acute myeloid leukemia

Y Chen, J Hu - Therapeutic advances in hematology, 2020 - journals.sagepub.com
Nucleophosmin (NPM1) is an abundant nucleolar protein that is implicated in a variety of
biological processes and in the pathogenesis of several human malignancies. For …

High PD-L1 Expression Predicts for Worse Outcome of Leukemia Patients with Concomitant NPM1 and FLT3 Mutations

B Brodská, P Otevřelová, C Šálek, O Fuchs… - International Journal of …, 2019 - mdpi.com
Compared to solid tumors, the role of PD-L1 in hematological malignancies is less explored,
and the knowledge in this area is mostly limited to lymphomas. However, several studies …

Proteostasis unbalance of nucleophosmin 1 in Acute Myeloid Leukemia: An aggregomic perspective

C Di Natale, D Florio, S Di Somma, A Di Matteo… - International Journal of …, 2020 - Elsevier
The role exerted by the nucleus in the regulation of proteostasis in both health and disease
is recognized of outmost importance, even though not fully understood. Many recent …

Cytoplasmic localization of Mdm2 in cells expressing mutated NPM is mediated by p53

D Strachotová, A Holoubek, K Wolfová… - The FEBS …, 2023 - Wiley Online Library
Specific C‐terminal nucleophosmin (NPM) mutations are related to the acute myeloid
leukaemia and cause mistargeting of mutated NPM (NPMmut) to the cytoplasm …

AML-related NPM mutations drive p53 delocalization into the cytoplasm with possible impact on p53-dependent stress response

A Holoubek, D Strachotová, P Otevřelová, P Röselová… - Cancers, 2021 - mdpi.com
Simple Summary Nucleophosmin (NPM) is one of the most abundant nucleolar proteins and
its mutations frequently occur in acute myeloid leukemia (AML). The mutations cause …

NSC348884 cytotoxicity is not mediated by inhibition of nucleophosmin oligomerization

M Šašinková, P Heřman, A Holoubek, D Strachotová… - Scientific Reports, 2021 - nature.com
Nucleophosmin (NPM) mutations causing its export from the nucleoli to the cytoplasm are
frequent in acute myeloid leukemia (AML). Due to heterooligomerization of wild type NPM …

Nucleolar phosphoprotein modifications as a marker of apoptosis induced by RITA treatment

K Wolfová, P Otevřelová, A Holoubek… - Biochimica et Biophysica …, 2023 - Elsevier
Abstract Reactivating p53 and Inducing Tumor Apoptosis (RITA) has been reported to
increase the p53 activity and to trigger p53-dependent apoptosis in cancer cells with wild …

[HTML][HTML] Global proteomic analysis of mesenchymal stem cells derived from human embryonic stem cells via connective tissue growth factor treatment under …

JH Seo, YJ Jeon - Journal of Microbiology and Biotechnology, 2022 - ncbi.nlm.nih.gov
Stem cells can be applied usefully in basic research and clinical field due to their
differentiation and self-renewal capacity. The aim of this study was to establish an effective …

Prognostication refinement in NPM1‐mutated acute myeloid leukemia stratified by FLT3‐ITD status with different induction doses of cytarabine

B Wang, X Hua, J Zhang, W Gu, H Li - Cancer Medicine, 2023 - Wiley Online Library
Objective We aimed to retrospectively discern the heterogeneity of outcomes from
clinicopathological characteristics and next‐generation sequencing (NGS) data in adult …