Captopril, the first orally active inhibitor of angiotensin-converting enzyme, is used widely in
the treatment of hypertension and congestive heart failure. The pharmacokinetics of this …

Captopril is an orally active inhibitor of angiotensin-converting enzyme (ACE) and has been
widely studied in the treatment of patients with mild to moderate essential hypertension …

The effects of intravenous captopril and intravenous digoxin given separately and in
combination on rest and exercise hemodynamics were studied in 16 patients with severe …

Recent studies have suggested the beneficial effects of angiotensin converting enzyme
(ACE) inhibitors against myocardial ischemic-reperfusion injury. This study was designed to …

Renal dysfunction occurring after open heart surgery is multifactorial in origin but activation
of the renin–angiotensin system may have a prominent role. Fourteen patients with …

Perindopril is an orally active, non-thiol angiotensin-converting enzyme (ACE) inhibitor,
which in doses of 4 to 8mg is effective in the control of essential hypertension. As …

The effect of captopril on coxsackievirus B3 murine myocarditis was investigated. Thirty-two,
3-week-old mice were infected with coxsackievirus B3 on day 0 of the study, then …

1. There is a body of circumstantial and direct evidence supporting the existence and
functional importance of a tissue based RAS at a variety of sites. 2. The relation between …

The response to ramipril, 10 and 20 mg on consecutive days, in 9 patients with severe (New
York Heart Association functional class III or IV) chronic congestive heart failure was …

The use of the angiotensin-converting enzyme inhibitor captopril in infants with congestive
heart failure (CHF) has been empirical owing to a lack of relevant pharmacokinetic data. To …