Unmasking the deceptive nature of cancer stem cells: The role of cd133 in revealing their secrets

J Pospieszna, H Dams-Kozlowska, W Udomsak… - International Journal of …, 2023 - mdpi.com
Cancer remains a leading cause of death globally, and its complexity poses a significant
challenge to effective treatment. Cancer stem cells and their markers have become key …

Tumor microenvironment-induced tumor cell plasticity: relationship with hypoxic stress and impact on tumor resistance

RF Zaarour, M Ribeiro, B Azzarone, S Kapoor… - Frontiers in …, 2023 - frontiersin.org
The role of tumor interaction with stromal components during carcinogenesis is crucial for
the design of efficient cancer treatment approaches. It is widely admitted that tumor hypoxic …

GART Functions as a Novel Methyltransferase in the RUVBL1/β‐Catenin Signaling Pathway to Promote Tumor Stemness in Colorectal Cancer

C Tang, M Ke, X Yu, S Sun, X Luo, X Liu… - Advanced …, 2023 - Wiley Online Library
Tumor stemness is associated with the recurrence and incurability of colorectal cancer
(CRC), which lacks effective therapeutic targets and drugs. Glycinamide ribonucleotide …

The role of alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinoma

Y Lu, B Lin, M Li - Frontiers in Oncology, 2024 - frontiersin.org
Hepatocellular carcinoma (HCC) is a prevalent malignant cancer worldwide, characterized
by high morbidity and mortality rates. Alpha-fetoprotein (AFP) is a glycoprotein synthesized …

Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular …

Q Wu, X Li, M Long, X Xie, Q Liu - Scientific Reports, 2023 - nature.com
Histone lysine lactylation (Kla) plays a vital role in the tumorigenesis of hepatocellular
carcinoma (HCC). Hence, we focused on Kla-specific genes to select novel therapeutic …

Rab11-FIP4 interacts with ARF5 to promote cancer stemness in hepatocellular carcinoma

F Song, Q Zhang, X Lu, T Xu, Q Hu, X Hu… - Journal of physiology …, 2023 - Springer
Recent studies suggest that Rab11-family interacting proteins (Rab11-FIPs) play an
important role in tumorigenesis and progression. Among the Rab11-FIPs, Rab11-FIP4 has …

Clonorchis sinensis infection amplifies hepatocellular carcinoma stemness, predicting unfavorable prognosis

Q Lin, Z Tang, Y Qin, X Deng, C Wei, F Liu… - PLOS Neglected …, 2024 - journals.plos.org
Background Extensive evidence links Clonorchis sinensis (C. sinensis) to
cholangiocarcinoma; however, its association with hepatocellular carcinoma (HCC) is less …

[HTML][HTML] RUNX2 prompts triple negative breast cancer drug resistance through TGF-β pathway regulating breast cancer stem cells

F Lv, W Si, X Xu, X He, Y Wang, Y Li, F Li - Neoplasia, 2024 - Elsevier
Triple-negative breast cancer (TNBC) stands out as the most aggressive subtype within the
spectrum of breast cancer. The current clinical guidelines propose treatment strategies …

Reappraisal of the Roles of the Sonic Hedgehog Signaling Pathway in Hepatocellular Carcinoma

KS Jeng, CF Chang, YM Tsang, IS Sheen, CJ Jeng - Cancers, 2024 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) remains one of the leading causes of
cancer mortality. Treatment of HCC remains challenging, especially for those with advanced …

[HTML][HTML] Combating drug resistance in hepatocellular carcinoma: No awareness today, no action tomorrow

F Jing, X Li, H Jiang, J Sun, Q Guo - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Hepatocellular carcinoma (HCC), the sixth most common cancer worldwide, is associated
with a high degree of malignancy and poor prognosis. Patients with early HCC may benefit …